• RUKIYA SAFA PATEL
• JYOTI MANTRI

Staphylococcus aureuscauses a range of infections, ranging from a simple boil to antibiotic-resistant infections to flesh-eating infections.Increased resistance to conventional antimicrobials has complicated the treatment of wound infections caused by Staphylococcus aureus. Phytochemicals, which are naturally present in plants have tremendous therapeutic potential and can be exploited in overcoming these infections. In this study, peels of pomegranate and banana, an agro-industrial waste were tested for their therapeutic properties to investigate their effectiveness as a new source of antimicrobials and wound healing agents. Powdered peel extracts of pomegranate and banana along with turmeric were prepared to study their antimicrobial activity along with their effect on Staphylococcus aureus pathogenesis. MIC/MBC values were determined and the presence of important phytochemicals were analyzed. A topical gel was formulated and evaluated for its physicochemical characteristics, stability and wound healing properties (Angiogenesis). According to the achieved results, banana peel extract showed the highest antimicrobial activity as compared to the other two. The virulence factors like Proteinase and Phospholipase of S. aureus were inhibited by the tested extracts.Therapeutically important phytochemicals such as tannins, flavonoids, glycosides, terpenoids and saponins were present in the studied extracts. The formulated gel showed enhanced angiogenesis, indicating its role in wound healing as evaluated by using chorioallantoic membrane assay

Antimicrobial resistance, banana peel, pomegranate peel, Staphylococcus aureus, topical gel, turmeric, wound healing.

"EVALUATION OF A TOPICAL FORMULATION CONTAINING EXTRACTS OF TURMERIC, POMEGRANATE AND BANANA PEEL ON STAPHYLOCOCCUS AUREUS PATHOGENESIS AND STUDYING ITS WOUND HEALING PROPERTIES.", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.6, Issue 5, page no.17-26, May-2019, Available :http://www.jetir.org/papers/JETIR1905I03.pdf

"EVALUATION OF A TOPICAL FORMULATION CONTAINING EXTRACTS OF TURMERIC, POMEGRANATE AND BANANA PEEL ON STAPHYLOCOCCUS AUREUS PATHOGENESIS AND STUDYING ITS WOUND HEALING PROPERTIES.", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.6, Issue 5, page no. pp17-26, May-2019, Available at : http://www.jetir.org/papers/JETIR1905I03.pdf