• Sowmya Tirumala
• Kartheek Kumar Allam
• Rajani Nanam
• Snigdha Endla
• Rajender Penthala

Introduction: Drug induced liver injury (DILI) is caused by several drugs. In our case report the patient presented with the relapse of TB and laboratory data shows elevated liver enzymes which might be due to anti-tubercular drugs, as the main adverse effect of ATT is hepatotoxicity which is majorly reported in 2-28% of patients. Case presentation: This was a relapse case of TB where the patient discontinued the treatment causing relapse of TB. Initially the patient was given with combination of all first line anti tubercular agents and the liver enzymes started raising above the normal levels indicating liver injury so, isoniazid, rifampicin and pyrazinamide were stopped which are majorly hepatotoxic. Ethambutol and streptomycin were given and the liver enzyme levels were normalized. Conclusion: The risk of affecting TB is greater in adults and persons who are immunocompromised. If left untreated, it leads to further complications like hemoptysis, septic shock, extra pulmonary TB, malignancy, chronic pulmonary aspergillosis. Timely detection and temporary withdrawal of offending agent can completely cure ATT induced liver injury.BCG vaccine helps in prevention of TB.

anti-tubercular therapy, hepatotoxicity, tuberculosis, aspergillosis, malignancy, hemoptysis.

"ANTI TUBERCULAR THERAPY INDUCED LIVER INJURY: A CASE REPORT", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.6, Issue 5, page no.49-52, May-2019, Available :http://www.jetir.org/papers/JETIR1905N09.pdf

"ANTI TUBERCULAR THERAPY INDUCED LIVER INJURY: A CASE REPORT", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.6, Issue 5, page no. pp49-52, May-2019, Available at : http://www.jetir.org/papers/JETIR1905N09.pdf