• BANSI ZALAVADIA
• DR.PRAGNESH PATANI

The aim of this work was to develop a tablet for the buccal delivery of the poorly water-soluble drug Fenofibrate which is a broad spectrum Fibric acid derivative used to reduce cholesterol levels in patients at risk of cardiovascular disease, for that an attempt was made to solubilize Fenofibrate by complexation with β- CD and then delivery via buccal mucosa. HPMC K4M and Carbopol 934P were selected as mucoadhesive polymers while Ethyl cellulose, as backing material. The complexation was studied by phase solubility method which indicates the formation of complex with 1:1 stoichiometry. The complexation was further characterized and studied by FTIR and DSC. Modification of the release for a poorly water-soluble drug, Fenofibrate, from hydrophilic matrices using cyclodextrin complexation was evaluated. The buccoadhesive tablets for the delivery of fenofibrate were prepared by 32 factorial designs by direct compression of HPMC K4M and Carbopol 934P. The tablets were evaluated for in vitro dissolution, surface pH, swelling study and mucoadhesive properties. The surface pH of all formulations was found to be within ±1 units of neutral pH hence these formulations should not cause any irritation in buccal cavity. Carbopol 934P showed superior bioadhesion properties compared to HPMC K4M. The in vitro release results demonstrated that drug is released by non-Fickian diffusion mechanism with zero order kinetics. From the drug release data, it was evident that formulation F2 (containing CP 15mg and HPMC K4M 20mg) has shown highly satisfactory values for dissolution parameters and has released approximatelt 98.53% drug in 6 hr. Hence, formulation F2 considered as the optimized buccal tablet containing Fenofibrate inclusion complex with β- CD for improved bioavailability.

Fenofibrate; β- Cyclodextrin; optimization; HPMC K4M; Carbopol 934P; Buccal delivery.

"FORMULATION AND EVALUATION OF MUCOADHESIVE BUCCAL TABLET OF FENOFIBRATE.", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.6, Issue 5, page no.425-437, May-2019, Available :http://www.jetir.org/papers/JETIR1905Q61.pdf

"FORMULATION AND EVALUATION OF MUCOADHESIVE BUCCAL TABLET OF FENOFIBRATE.", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.6, Issue 5, page no. pp425-437, May-2019, Available at : http://www.jetir.org/papers/JETIR1905Q61.pdf