• DR PARNAJYOTI KARMAKAR

The spectrophotometric study of the interactions of the title complex with DL-penicillamine, a bio-molecule, in aqueous medium as a function of [substrate complex], [ligand], and temperature at constant ionic strength have been performed. The interactions with the studied ligands reveal two phases at pH 4.0: the first is dependent on ligand concentration, while the second is independent. An associative activation mechanism for interaction process is proposed based on the experimental data. The activation parameters and the thermodynamic parameters were computed using the temperature dependences of the outer sphere association, which supports the spontaneous formation of an outer sphere association complex. The product of this reaction has been characterized with the help of Job’s method and IR spectroscopic analysis. The bio-active nucleophile's reactivity pattern towards the substrate complex has been discussed, which throws more light on the mechanistic behaviour of platinum(II) antitumor complexes.

Mechanism • UV/Vis spectroscopy • Platinum(II) • DL-penicillamine

"Mechanistic aspects of the ligand substitution reactions on cis-[Pt(1,3-diaminopropane) (H2O)2] 2+ ion with important bio-molecule in aqueous medium", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.6, Issue 5, page no.1-8, May-2019, Available :http://www.jetir.org/papers/JETIR1905X01.pdf

"Mechanistic aspects of the ligand substitution reactions on cis-[Pt(1,3-diaminopropane) (H2O)2] 2+ ion with important bio-molecule in aqueous medium", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.6, Issue 5, page no. pp1-8, May-2019, Available at : http://www.jetir.org/papers/JETIR1905X01.pdf