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Published in:

Volume 7 Issue 5
May-2020
eISSN: 2349-5162

Unique Identifier

JETIR2005187

Page Number

323-329

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Title

mRNA– i TECHNOLOGY- A NOVEL AND UNIQUE APPROACH AND STRATEGY FOR PROPHYLAXIS AND TREATMENT

ISSN

2349-5162

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"mRNA– i TECHNOLOGY- A NOVEL AND UNIQUE APPROACH AND STRATEGY FOR PROPHYLAXIS AND TREATMENT ", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.7, Issue 5, page no.323-329, May-2020, Available :http://www.jetir.org/papers/JETIR2005187.pdf

Abstract

RNAi is a natural cellular progression of gene silencing that represents one of the most promising and rapidly advancing frontiers in microbiology and drug invention today. Its discovery has been considered as “a major scientific breakthrough that happens once every decade or so,” and was recognized with the award of the 2006- Nobel Prize for Physiology or Medicine. RNAi is an adaptive cellular defense mechanism, is a worldwide denominator for the Post-transcriptional Gene Silencing (PTGS) phenomenon observed in a variety of living species including plants and animals. It is a dominant reverse genetic procedure that has been extensively employed to silence gene expression in human cells. RNAi- based gene therapies, especially in viral diseases have become more and more interesting and promising. Recently, siRNA can be used to defend host from viral infection, inhibit the expression of viral antigen and accessory genes, control the transcription and replication of viral genome, obstruct the assembly of viral particles, and display influences in virus-host interactions. Literature and early reports suggest that biologists have applied RNAi technology to combat number of viral infections. They have also developed RNAi library to study the function of genes in human body, which can smoothen the task of the identification of drug targets against any kind of viral infection. Though further research is necessary to be carried out by geneticists and biotechnologists to develop such a unique and novel RNAi technique to prevent HCoV 2 infection and find out siRNA (Small interfering RNA) based antiviral therapy or vaccine for COVID-19. COVID-19; HCoV 2; Post-transcriptional Gene Silencing; RNAi; siRNA.

Key Words

COVID-19; HCoV 2; Post-transcriptional Gene Silencing; RNAi; siRNA.

Cite This Article

"mRNA– i TECHNOLOGY- A NOVEL AND UNIQUE APPROACH AND STRATEGY FOR PROPHYLAXIS AND TREATMENT ", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.7, Issue 5, page no. pp323-329, May-2020, Available at : http://www.jetir.org/papers/JETIR2005187.pdf

Publication Details

Published Paper ID: JETIR2005187
Registration ID: 231881
Published In: Volume 7 | Issue 5 | Year May-2020
DOI (Digital Object Identifier):
Page No: 323-329
ISSN Number: 2349-5162

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Cite This Article

"mRNA– i TECHNOLOGY- A NOVEL AND UNIQUE APPROACH AND STRATEGY FOR PROPHYLAXIS AND TREATMENT ", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.7, Issue 5, page no. pp323-329, May-2020, Available at : http://www.jetir.org/papers/JETIR2005187.pdf




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