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Published in:

Volume 7 Issue 5
May-2020
eISSN: 2349-5162

Unique Identifier

JETIR2005242

Page Number

721-744

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Title

Mitochondrial Dysfunction In Aging Related Diseases; potential mitochondrial based therapeutics in Sarcopenia and Age-related Macular Degeneration.

ISSN

2349-5162

Cite This Article

"Mitochondrial Dysfunction In Aging Related Diseases; potential mitochondrial based therapeutics in Sarcopenia and Age-related Macular Degeneration.", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.7, Issue 5, page no.721-744, May-2020, Available :http://www.jetir.org/papers/JETIR2005242.pdf

Abstract

Aging represents a major scientific and social hurdle of mankind since the inception of life. This is as a result of decline in metabolic function and organelle power leading to varying degrees of aging related disease such as neurodegenerative disease, cardiovascular disease, optical defects, neuromuscular compromise etc. Of utmost interest in this review is aging-related disease sarcopenia and the eye deteriorating Age-related Macular Degeneration. Sarcopenia is a major muscle threatening condition emerging as a result of low muscle mass and muscle function and Age-related Macular Degeneration is a great cause of blindness globally. Previous studies have reported sarcopenia and age-related macular degeneration as a multi factorial disease induced by various mechanism such as physical inactivity, oxidative stress, mitochondrial dysfunction, inflammation, insulin resistance, cigarette smoking, sunlight exposure, genetic factors, and endocrine factors, all resulting in the pathogenesis of frailty associated with aging, thus reducing the quality of healthy life. Despite the growing risk factors in age-related diseases, there are increasing reports implicating mitochondrial dysfunction playing a prominent role in sarcopenia and Age-related Macular Degeneration. In addition, various therapeutics have been reported in management of age-related diseases most notably exercise, protein supplements, drugs, vitamin D and gene therapy. Recent studies points at mitochondrial based therapeutics as a promising prospect in managing age-related diseases. In lieu of that, this review affirms the plausibility of mitochondrial and aging, and examines the role of mitochondrial dysfunction in aging related diseases. Finally, explores some potential mitochondrial based therapeutics in management of sarcopenia and Angular Macular Dysfunction

Key Words

Aging, Mitochondrial Dysfunction, Sarcopenia, Age-related Macular Degeneration, Therapeutics.

Cite This Article

"Mitochondrial Dysfunction In Aging Related Diseases; potential mitochondrial based therapeutics in Sarcopenia and Age-related Macular Degeneration.", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.7, Issue 5, page no. pp721-744, May-2020, Available at : http://www.jetir.org/papers/JETIR2005242.pdf

Publication Details

Published Paper ID: JETIR2005242
Registration ID: 232321
Published In: Volume 7 | Issue 5 | Year May-2020
DOI (Digital Object Identifier):
Page No: 721-744
ISSN Number: 2349-5162

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Cite This Article

"Mitochondrial Dysfunction In Aging Related Diseases; potential mitochondrial based therapeutics in Sarcopenia and Age-related Macular Degeneration.", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.7, Issue 5, page no. pp721-744, May-2020, Available at : http://www.jetir.org/papers/JETIR2005242.pdf




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