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Published in:

Volume 7 Issue 6
June-2020
eISSN: 2349-5162

Unique Identifier

JETIR2006481

Page Number

1023-1033

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Title

Antioxidant biochemical enzyme activities of Adansonia digitata L. in ulcer induced experimental male Wistar rats

ISSN

2349-5162

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"Antioxidant biochemical enzyme activities of Adansonia digitata L. in ulcer induced experimental male Wistar rats", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.7, Issue 6, page no.1023-1033, June-2020, Available :http://www.jetir.org/papers/JETIR2006481.pdf

Abstract

Abstract: To investigate the conceivable antioxidant capacity of Adansonia digitata L, The present study focused on the alterations in antioxidant enzymatic activities. With a specific end goal to investigate the impacts of oxidant prevention agent protections on the procedure of ulceration, in all stomach tissues, the cell reinforcement levels were assessed. The level of Glutathione (GSH), Glutathione Reductase (GR), Glutathione s transferase (GST), superoxide dismutase (SOD), catalase (CAT), and Glutathione Peroxidase (GPx) were assessed in ulcer control, Standard and drug treated group. Aqueous and Alcoholic extracts of Adansonia digitata L. leaves (AAD and EAD) demonstrated a dosage dependant antioxidant action (p<0.05) in every anti ulcer model. Ethanol in ulcer incited rats created depletion in the accompanying enzymes, GSH, GR, GPx, GST, SOD and CAT. In every distinctive concentration raising from 100 to 200 mg/kg, AAD 200mg/kg has shown the basic and earth shattering effect in each and every enzymatic examination, This is just about demonstrating near to effect to the standard drug Ranitidine. Glutathione levels of AAD 200mg/kg have shown 5.560 ± 0. 380 compare with standard drug 6.632 ± 0.372 and GR levels as 28.73 ±0.947 where as standard has shown 30.14 ± 0.786. AAD 200 has shown significant increase in GPx levels also compared to ulcer rats. AAD 200 extract has also shown a significant increase in GST levels compared with EAD and AAD extracts. Our current study demonstrated the probable role of antioxidant enzymes in scavenging reactive oxygen species (ROS) associated with tolerance to gastric ulcer.

Key Words

: Adansonia digitata, anti oxidant, GST, GR, GPx, SOD, Biochemical enzymes

Cite This Article

"Antioxidant biochemical enzyme activities of Adansonia digitata L. in ulcer induced experimental male Wistar rats", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.7, Issue 6, page no. pp1023-1033, June-2020, Available at : http://www.jetir.org/papers/JETIR2006481.pdf

Publication Details

Published Paper ID: JETIR2006481
Registration ID: 234719
Published In: Volume 7 | Issue 6 | Year June-2020
DOI (Digital Object Identifier):
Page No: 1023-1033
ISSN Number: 2349-5162

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Cite This Article

"Antioxidant biochemical enzyme activities of Adansonia digitata L. in ulcer induced experimental male Wistar rats", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.7, Issue 6, page no. pp1023-1033, June-2020, Available at : http://www.jetir.org/papers/JETIR2006481.pdf




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