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Published in:

Volume 7 Issue 7
July-2020
eISSN: 2349-5162

Unique Identifier

JETIR2007172

Page Number

1394-1399

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Title

A summary of Native Chemical Ligation and it’s Application in Protein Therapeutics.

ISSN

2349-5162

Cite This Article

"A summary of Native Chemical Ligation and it’s Application in Protein Therapeutics.", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.7, Issue 7, page no.1394-1399, July-2020, Available :http://www.jetir.org/papers/JETIR2007172.pdf

Authors

Abstract

Native Chemical Ligation reactions are known from the last two decades and they emerge tremendous scope for chemical synthesis of large proteins. Proteins are the building blocks of any biological system. Native chemical ligation provides a platform to prepare homogeneous proteins with or without post-translational modifications. Here we summarize how native chemical ligation evolved and overcome limitations of conventional chemical ligation. In this review, we discussed the utility and various types of Native chemical Ligation reactions. Further these reactions lead to applicable in the development of protein therapeutics. Application of Protein therapeutics discussed with its pro and cons.

Key Words

Native Chemical Ligation, Post-translational modification,Proteins, Therapeutics

Cite This Article

"A summary of Native Chemical Ligation and it’s Application in Protein Therapeutics.", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.7, Issue 7, page no. pp1394-1399, July-2020, Available at : http://www.jetir.org/papers/JETIR2007172.pdf

Publication Details

Published Paper ID: JETIR2007172
Registration ID: 235127
Published In: Volume 7 | Issue 7 | Year July-2020
DOI (Digital Object Identifier):
Page No: 1394-1399
ISSN Number: 2349-5162

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Cite This Article

"A summary of Native Chemical Ligation and it’s Application in Protein Therapeutics.", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.7, Issue 7, page no. pp1394-1399, July-2020, Available at : http://www.jetir.org/papers/JETIR2007172.pdf




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