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Published in:

Volume 7 Issue 10
October-2020
eISSN: 2349-5162

Unique Identifier

JETIR2010158

Page Number

1239-1247

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Title

REVIEW ON HYPOXANTHINE GUANINE PHOSPHORIBOSYL TRANSFERASE (HGPRT)

ISSN

2349-5162

Cite This Article

"REVIEW ON HYPOXANTHINE GUANINE PHOSPHORIBOSYL TRANSFERASE (HGPRT)", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.7, Issue 10, page no.1239-1247, October-2020, Available :http://www.jetir.org/papers/JETIR2010158.pdf

Abstract

Hypoxanthine-guanine phosphoribosyl transferase (HGPRT) is a purine salvage enzyme that shows significant role in regulation of purine metabolism in human. HGPRT has been produced to give a creature model to the infection of Lesch-Nyhan disorder. The commonness of Lesch–Nyhan ailment is unsurprising to be roughly 1/380 000 live births, making it quite rare. Ordinarily, influenced patients have a typical pre-birth and perinatal course followed by advancement of signs for the most part inside 3–6 months. The hereditary condition Lesch-Nyhan disorder, which is brought about by a protein hypoxanthine phosphoribosyl transferase (HPRT) deficiency is characterized by behavioural changes, including self-injurious behavior and intellectual retention [1].The current-considers were led to portray the results of the transformation on the declaration of HPRT and to describe potential changes in cerebrum purine content in these freaks. These outcomes demonstrate that the freak creatures have no noticeable HPRT-immunoreactivity material on western marks and no perceptible HPRT chemical movement in cerebrum tissue homogenates, Several various changes have been distinguished all through the coding area, however without exact data on the HPRT protein'3D dimensional structure, it remains difficult to determine any consistent correlation between the Structure and function of the enzyme. Selective inhibition of the enzymes HGPRT of parasite vs human are likely to be required as one of novel approach for treatment of malaria. In the present study, designing and virtual screening of PFHGPRT inhibitors could help in guiding medicinal chemists to improve target specificity for antimalarial chemotherapy.

Key Words

Hypoxanthine-guanine phosphoribosyl transferase, Lesch-Nyhan disease, Purine metabolism, antimalarial, 3D structure of HGPRT.

Cite This Article

"REVIEW ON HYPOXANTHINE GUANINE PHOSPHORIBOSYL TRANSFERASE (HGPRT)", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.7, Issue 10, page no. pp1239-1247, October-2020, Available at : http://www.jetir.org/papers/JETIR2010158.pdf

Publication Details

Published Paper ID: JETIR2010158
Registration ID: 302002
Published In: Volume 7 | Issue 10 | Year October-2020
DOI (Digital Object Identifier):
Page No: 1239-1247
ISSN Number: 2349-5162

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Cite This Article

"REVIEW ON HYPOXANTHINE GUANINE PHOSPHORIBOSYL TRANSFERASE (HGPRT)", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.7, Issue 10, page no. pp1239-1247, October-2020, Available at : http://www.jetir.org/papers/JETIR2010158.pdf




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