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"EVALUATE THE ROLE OF PROCALCITONIN AND C-REACTIVE PROTEIN AS A ENCOURAGING BIOMARKERS FOR DIAGNOSING PEDIATRIC SEPSIS", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.8, Issue 2, page no.429-438, February-2021, Available :http://www.jetir.org/papers/JETIR2102047.pdf

• Harish Chandra Pandey
• Dr Kalpana Sharma
• Kaptan Singh Sehrawat
• 4Hari Mohan Jangid

Diagnosis of Pediatric Sepsis is a challenge because of its nonspecific presentation together with low sensitivity of the time-consuming bacterial cultures. Sepsis markers, like C-reactive protein (CRP), and procalcitonin (PCT), have encouraging results to improve its diagnosis. This study was done to investigate the role of CRP and PCT in promoting the early diagnosis of pediatric sepsis an attempt to decrease morbidity and mortality. Methods: This prospective study was conducted on 122 children age between 2 days to 10 years suspected with sepsis enrolled in tertiary care hospital of North India. Blood cultures for these patients were done before starting antibiotics. Measurements of CRP using the immunoturbidimetry method, PCT using electrochemiluminescence were done to all enrolled patients. Total leucocytes count (TLC) was performed on Sysmex KX-21 analyzer. Results: Forty-four children with proved sepsis were found to be positive in blood culture. The most common isolated organisms were Klebsiella (54.55%), followed by E. coli (13.64%) CONS (11.37%), Staph aureus (9.09%), GBS (6.81%) and Citrobacter (4.54%). We detected much significant higher levels of PCT and CRP in the proved sepsis group than the suspected pediatric sepsis cases. TLC, Serum PCT and CRP levels showed the highest sensitivity of 90.9%, 90.9% and 84.1%; specificity of 65.4%, 74.5% and 70.5% respectively. PPV of 59.7%, 66.7% and 61.7%; NPV of 92.7%, 93.5%, and 88.7% respectively. Conclusion: PCT and CRP along with TLC together has satisfactory characteristics as a good marker for the diagnosis of pediatric sepsis.

Procalcitonin, C-reactive protein, TLC, Paediatric sepsis

"EVALUATE THE ROLE OF PROCALCITONIN AND C-REACTIVE PROTEIN AS A ENCOURAGING BIOMARKERS FOR DIAGNOSING PEDIATRIC SEPSIS", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.8, Issue 2, page no. pp429-438, February-2021, Available at : http://www.jetir.org/papers/JETIR2102047.pdf