• Archita Srivastava
• Dr. Sunil Kumar Singh
• Prof. Dr. Alok Mukerjee
• Dr. Abhishek Tripathi
• Ashvani Tripathi

The display think about was conduct to look at the impression of a binge-feeding within the frame of highfat slim down (HFD) having impacts on liquor utilization, behavior action and level of engine cortex oxidative harm. To do this, female wistar rats gotten rat chow and Discontinuous or unremitting HFD for 6 weeks. Rat chow and water were accessible ad-libitum to all bunches all through the try. Taking after 6 weeks of HFD cycling, 20.0% ethanol or water admissions was assessed from last 3 weeks by the assistance of Discontinuous get to 2 bottle choice worldview in dark phase. In expansion, anxiety-like behavior was measured employing a light-dark demonstrate and lifted additionally labyrinth, and learning and locomotor action by Morris water labyrinth or Rota bar demonstrate was moreover performed after which the estimation of oxidative push was too taken note. Strikingly, irregular access HFD rats shown lower liquor utilization with more admissions of HFD instead of rat chow. Rats uncovered to HFD went through more time within the ligh/tand maintain the balance on Rota rod and easily found the hidden platform on water maze. It represents that binge-feeding has anxiolytic effects. Further investigation for oxidative stress marks that MDA returns near to the normal value in those groups of animals which were exposed to HFD in chronic or intermittent way as compared to positive control who only consumed alcohol without HFD exposure, similarly there is no alteration in SOD level. The study revealed that animals which were treated with HFD in chronic and intermittent manner has consumed less alcohol as compared to non HFD groups, and also found that behavior alteration was minor with HFD. Intermittent exposure group showed more significant reduction in alcohol consumption, anxiolytic activity, as well learning and motor balance activity and oxidative stress range as compared to chronic HFD.

Behavior activity, HFD, Ethanol, oxidative stress, female wistar rat, Motor cortex.

"Female Rat Induce Behaviour Impairment and oxidative damage in Motor Cortex After Alcohol consumption and Altered by HighFatDiet", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.9, Issue 3, page no.e762-e776, March-2022, Available :http://www.jetir.org/papers/JETIR2203500.pdf

"Female Rat Induce Behaviour Impairment and oxidative damage in Motor Cortex After Alcohol consumption and Altered by HighFatDiet", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.9, Issue 3, page no. ppe762-e776, March-2022, Available at : http://www.jetir.org/papers/JETIR2203500.pdf