• Sanjay G.Bhuktare
• Chandrakant P.Rathod

The aim of present work was to formulate extended drug delivery system of Metoprolol tartrate suitable for once-a-day dosing. HPMC in various grades like K4M, K15M and K100M were screened firstly in an increasing drug to polymer ratio (1:1, 1:1.5, and 1:2) and then selected grade was combined with Carbapol-940 and also carbapol-940 combine with chitosan, sodium alginate in ratio (1:1).Pre-compression parameter of powder blend was carried out which shown the results within prescribed compendia limits. Direct compression method was adopted for the preparation of sustained release matrix tablets. The values for thickness, hardness, % friability, weight variation and content uniformity parameters were found to be within the prescribed limits and were confirmed to the pharmacopoeial requirements. The % drug release studies for combined HPMC-K4M and Carbapol-940 matrices confirmed the batch B6 (1:1) ratio at the end of 8 hours which give the 101.31% drug release. Formulation was optimized and subjected to release kinetic study and accelerated stability studies.

Keywords- Metoprolol tartrate, carbapol-940, Pre-compression, kinetic study

"Design, Fabrication and evaluation of Metoprolol tartrate once a day Matrix tablet.", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.9, Issue 9, page no.d88-d100, September-2022, Available :http://www.jetir.org/papers/JETIR2209312.pdf

"Design, Fabrication and evaluation of Metoprolol tartrate once a day Matrix tablet.", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.9, Issue 9, page no. ppd88-d100, September-2022, Available at : http://www.jetir.org/papers/JETIR2209312.pdf