• Sanket Dinkar Dhakane
• Pallavi Tukaram Jadhav

Post-traumatic epilepsy (PTE) is one of the most destructive long-term, recurrent seizure disorder in network consequences of traumatic brain injury following head trauma. PTE is not a homogeneous Condition and can appear several years after the head injury. Severe TBI, after a period of time, causes numerous neuropsychiatric and neurodegenerative problems or neurological impairments with varying comorbidities, and brain homeostasis may never be restored. The anti-epileptic drugs (AEDs) are used as preventive strategies to manage TBI, control the frequency of acute Seizures and prevent development of PTE their efficacy in PTE remains controversial. Simultaneously, there have been repeated recommendations by radiologists and neuroimaging experts for the incorporation of localization based on electroencephalography (EEG) into the Process of clinical decision-making regarding PTE patients. While seizure or prophylaxis can prevent early onset seizures, there are no available treatments effectively prevent late-onset seizure. The purpose of this review is to discuss the current state of knowledge pertaining to neuroprotection in epileptic conditions, by increasing understanding about post-traumatic epilepsy and injury expansion over time, it will be possible to design better treatments with specific molecular targets to prevent late-onset seizure occurrence following traumatic brain injury. to investigate the epidemiology and the risk factors for post-traumatic epilepsy (PTE) in a large cohort of patients after severe non-penetrating civilian traumatic brain injury (TBI).Finally describe current and novel treatments and management strategies for preventing PTE. The review provides an opportunity for researchers and health service professionals to better understand the underlying pathophysiology of PTE to develop novel, more effective therapeutic targets and to improve the quality of life of people with this condition.

posttraumatic epilepsy, seizures, comorbidities, Traumatic Brain Injury, antiepileptic drugs Prophylaxis.

" POST TRAUMATIC EPILEPSY AND COMORBIDITIES: AN OVERVIEW ", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.9, Issue 11, page no.d719-d735, November-2022, Available :http://www.jetir.org/papers/JETIR2211398.pdf

" POST TRAUMATIC EPILEPSY AND COMORBIDITIES: AN OVERVIEW ", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.9, Issue 11, page no. ppd719-d735, November-2022, Available at : http://www.jetir.org/papers/JETIR2211398.pdf