• Diksha Mishra
• Dr Javin Bishnu Gogoi

Metabolic syndrome is a serious health condition that affects about 23 percent of adults and puts them at high risk for fat-related heart disease, diabetes, stroke and arterial wall disease. With the successful conquest of many chronic infectious diseases in the world, non-communicable disease (NCD) has become a major cause of morbidity and mortality not only in the developed countries but also in the less developed countries. Among all these NCDs, metabolic syndrome has been a real epidemic worldwide. Insulin resistance, visceral cholesterol, atherogenic dyslipidemia, endothelial dysfunction, genetic predisposition, hypertension, hyper-coagulable status and chronic stress are among the many factors that contribute to the development of the syndrome. Chronic inflammation is known to be associated with visceral obesity and insulin resistance, which is characterized by the production of abnormal adipocytes such as tumor necrosis factor α, interleukin-1 (IL-1), IL-6, leptin, and adiponectin. The interaction between the components of the clinical phenotype of the syndrome contributes to the development of its biological phenotype (insulin resistance, dyslipidemia, etc.), a pro-inflammatory state, and alters chronic, subclinical vascular inflammation and the formation of atherosclerotic processes. Lifestyle change is the initial intervention of choice for such people. Modern lifestyle modification therapy integrates specific recommendations regarding diet and exercise with behavioral strategies. Pharmacological treatment should be considered for those whose risk factors are not adequately reduced with lifestyle changes. This review provides a summary of the literature regarding the definition of the syndrome, the epidemiology, the underlying pathogen formation, and the treatment approaches for each risk factor, including metabolic syndrome.

Metabolic syndrome, Modern lifestyle, modification therapy etc.

"A CRITICAL INTERPRETATION ON THE CONCEPT OF METABOLIC SYNDROME – A REVIEW STUDY", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.10, Issue 1, page no.d156-d176, January-2023, Available :http://www.jetir.org/papers/JETIR2301320.pdf

"A CRITICAL INTERPRETATION ON THE CONCEPT OF METABOLIC SYNDROME – A REVIEW STUDY", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.10, Issue 1, page no. ppd156-d176, January-2023, Available at : http://www.jetir.org/papers/JETIR2301320.pdf