• Ankalesha S. Gopalghare
• Dr. Mrunal K. Shirsat
• Dr. Santosh R. Tarke
• Naresh R. Jaiswal
• Sneha S. Marapalle

According to present work is based on the Formulation and Evaluation of Transdermal Gel of Ketoprofen with Natural Gelling Agent From Ocimum Basilicum Seed Mucilage and Penetration Enhancer is Menthol for Treatment in Musculoskeletal Disorder such as rheumatoid arthritis, osteoarthritis, and spondylitis by using dispersion method. Gel were prepared by dispersing method where polymer such as OBM ( Ocimum Basilicum Seed Mucilage) is dispersed over water for 2 hours till the polymer is soaked with water, after that other chemical ingredients are mixed and stirred well until a homogenous mass is obtained. The dispersion was then neutral. The OBM gel of ketoprofen were found to be homogenous with good drug loading. The pH of all the gel formulation was found within the neutral pH range which is compatibility with skin and viscosity of formulation was found to be feasible for topical drug delivery. Result of in-vitro drug release study shows that f4 formulation. It has better diffusion of drug through egg membrane and hence further permeation studies carried out through HET-CAM test was used for the in-vitro assessment of skin irritation of the prepared gel sample. The compatibility study showed that the major peaks in FTIR spectra of the pure drug were found to be intact in their physical mixture. Hence there is no interaction between drug and OBM in their physical mixture. OBM can be effectively used as the polymer for topical gel preparation. F4 formulation containing OBM may be effectively used as topical transdermal delivery for ketoprofen. Transdermal gel is one among the dosage form lying under the category of controlled drug delivery, during which the aim is to deliver the drug through the skin within a predetermined and controlled rate. The transdermal Penetration and pharmacological efficiency of ketoprofen is superior because of it’s intermediate log P value (3.12) Thus the present topic is undertaken for resolve limitations of conventional route of administration and improve patient compliance.

Ketoprofen, NSAID, Penetration Enhancer(menthol), OBM (Natural gelling agent), Transdermal gel, Data analysis and release kinetics, compatibility study, dispersion method, Anti- inflammatory Activity.

"FORMULATION AND EVALUATION OF TRANSDERMAL GEL OF KETOPROFEN WITH NATURAL GELLING AGENT FROM OCIMUM BASILICUM SEED AND PENETRATION ENHANCER IS MENTHOL", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.10, Issue 7, page no.h379-h395, July-2023, Available :http://www.jetir.org/papers/JETIR2307749.pdf

"FORMULATION AND EVALUATION OF TRANSDERMAL GEL OF KETOPROFEN WITH NATURAL GELLING AGENT FROM OCIMUM BASILICUM SEED AND PENETRATION ENHANCER IS MENTHOL", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.10, Issue 7, page no. pph379-h395, July-2023, Available at : http://www.jetir.org/papers/JETIR2307749.pdf