• Akanksha Tripathi
• Mrs. Roshan Zehra
• Dr.Amarjeet Singh

Abstract Appropriate delivery of drug to the sites is crucial via conventional drug delivery system. A controlled and sustained release system microsphere loaded with vancomycin was developed by using porous and pH-responsive poly(lactic-co-glycolic acid) (PLGA). The microspheres, developed through the W/O/W double-emulsion evaporation method, comprised a PLGA-based shell and a core containing Vancomycin.To promote colon targeting of the systems was directly coated with poly(methacrylic acid-co-methyl methacrylate) (Eudragit-S100). The optimized preparation conditions for PLGA–Eudragit–Van microspheres were investigated and characterized, and it demonstrated as a porous microstructures with regular shape and uniform size and the characteristic of controlled drug release, The results of the study showedits further utilization for the treatment of septic arthritis.

Keywords:Polylactic-co-glycolic acid,Targeted drug delivery system, Eudragit-S100, Septic Arthritis

" A Review Article on Formulation and Evaluation of Vancomycin Loaded Microsphere for the Treatment of Septic Arthritis", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.10, Issue 7, page no.i130-i135, July-2023, Available :http://www.jetir.org/papers/JETIR2307820.pdf

" A Review Article on Formulation and Evaluation of Vancomycin Loaded Microsphere for the Treatment of Septic Arthritis", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.10, Issue 7, page no. ppi130-i135, July-2023, Available at : http://www.jetir.org/papers/JETIR2307820.pdf