• Siddharthan Lakshmanan

Telomerase is an excellent biomarker for cancer detection as compared to normal cells almost all of the human cancers cells express high levels of telomerase to add to the proliferative effect of these cells. Telomerase activity can be identified by its catalytic protein domain telomerase reverse transcriptase. These are part of an important subgroup of RNA-dependent polymerases. The main function of this molecule is to lengthen telomeres in DNA strands, thereby allowing senescent cells that would otherwise become postmitotic and undergo apoptosis to exceed their lifespan become potentially immortal, as is often the case with cancerous cells. At a molecular level, telomerase is responsible for catalyzing the addition of nucleotides in a TTAGGG sequence to the ends of a chromosome’s telomeres, thereby preventing degradation of the chromosomal ends following multiple rounds of replication. There are various regulatory mechanisms that ensure that TERT target shorter telomeres rather than longer ones and in this way do not contribute to aberrant telomere elongation that may lead to Cancer. Having said that, TERT play an important role in cancer cell’s rapid proliferation because it directly impacts how many times a cell can divide and thus is capable of inducing immortality in cells.

In silico study of BIBR1532 and other TERT inhibitors

"In silico study of BIBR1532 and other TERT inhibitors", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.10, Issue 7, page no.i151-i164, July-2023, Available :http://www.jetir.org/papers/JETIR2307822.pdf

"In silico study of BIBR1532 and other TERT inhibitors", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.10, Issue 7, page no. ppi151-i164, July-2023, Available at : http://www.jetir.org/papers/JETIR2307822.pdf