• DEEPA CHAUHAN
• QUMRE ALAM
• Dr.Amarjeet Singh
• AKASH JOHRI

ABSTRACT Diabetic nephropathy is a severe complication of diabetes mellitus and a leading cause of end-stage renal disease (ESRD) worldwide. Various rat models of diabetic nephropathy have been developed over the years, each with its strengths and limitations. Understanding these models and their translational relevance is critical for developing effective therapeutic strategies for this debilitating condition. In this review article, we provide a comparative analysis of various rat models of diabetic nephropathy, highlighting their strengths and limitations, and discussing their translational relevance. We examine the key pathological features of diabetic nephropathy recapitulated in these models, including mesangial expansion, glomerular hypertrophy, proteinuria, and tubulointerstitial fibrosis. Among the different rat models of diabetic nephropathy, the streptozotocin (STZ) model is the most commonly used model, but it has limitations in recapitulating the natural history of human diabetic nephropathy. Other models include the Akita model and the Zucker diabetic fatty (ZDF) model, each with their own strengths and limitations. Despite these limitations, rat models of diabetic nephropathy remain an essential tool for studying the pathophysiology of this condition and for developing new therapeutic strategies. Recent advances in genetic engineering and stem cell technologies have led to the development of more sophisticated rat models that closely mimic the pathophysiology of human diabetic nephropathy. These models hold great promise for improving our understanding of diabetic nephropathy and for developing new and effective therapies for patients with this condition.

Keywords: Diabetic nephropathy, rat models, streptozotocin, Akita, Zucker diabetic fatty, pathophysiology, therapeutic strategies, genetic engineering, stem cell technologies.

" A Review Article on Comparative analysis of various rat models of diabetic nephropathy: Strengths, limitations, and translational relevance", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.10, Issue 7, page no.i581-i586, July-2023, Available :http://www.jetir.org/papers/JETIR2307883.pdf

" A Review Article on Comparative analysis of various rat models of diabetic nephropathy: Strengths, limitations, and translational relevance", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.10, Issue 7, page no. ppi581-i586, July-2023, Available at : http://www.jetir.org/papers/JETIR2307883.pdf