• Khushboo Lavania
• Avdhesh Sharma

ABSTRACT The major objective of the present work is to formulate and characterize Silymarin-loaded matrix tablets using Karaya Gum Powder as a release-controlling polymer. The matrix tablets were prepared by using the wet granulation method and characterized for their quality control attributes including hardness, weight variation, friability, and content uniformity. Further, matrix tablets were also characterized for their in-vitro release in phosphate buffer pH 6.8 using the Paddle type dissolution apparatus. The release kinetics models were applied to the dissolution data to predict the mechanism of release. The effect of increasing the concentration of Karaya gum on the release rate was studied. All the prepared batches of matrix tablets containing Silymarin have shown good quality control attributes and passed the requirements. The release rate of Silymarin was found to be decreased with increasing the concentration of Karaya gum in matrix tablets. The release kinetic model indicated the zero-order release for the matrix tablets prepared with Silymarin and Karaya gum in a ratio of 1:1.25. The storage stability of the optimized batch of matrix tablets was also carried out up to 60 days under 40°C and 75% RH. The result showed no color change and no significant difference in the percentage of drug release. Hence, the optimized batch of matrix tablets was found to be stable.

Silymarin, Karaya Gum, Matrix Tablet, Zero-order, Hepatoprotective.

"Formulation and evaluation of Silymarin loaded Matrix Tablets using Karaya gum ", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.10, Issue 7, page no.i587-i597, July-2023, Available :http://www.jetir.org/papers/JETIR2307884.pdf

"Formulation and evaluation of Silymarin loaded Matrix Tablets using Karaya gum ", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.10, Issue 7, page no. ppi587-i597, July-2023, Available at : http://www.jetir.org/papers/JETIR2307884.pdf