• M.harshini

Carbon monoxide (CO), which is produced as a By-product of heme oxidation by the heme oxygenase(HO) enzyme imparts cytotoxicity in the biological organisms at higher concentrations because binding affinity of CO to hemoglobin when compared to oxygen.so,it was considered to be lethal earlier. In recent days, evidences from extensive research on biological activity has been proved that the release of CO from prodrug CO-releasing molecules (CO-RMs) have significant role in various pharmacological activities when administered in controlled pattern into the cellular systems than direct administration of CO. Based upon the covalent bond formation between CO and metal carbonyl complexes (MCCs) many CORMs are produced such as CORM-1, CORM-2, CORM-3, ALF492, CORM-A1 and ALF186. Inversely, degradation of CORMs generate a metal residue (i-CORMs) which lead to toxicity in the body,Inorder to minimize this effect new CORMats such as micellization, nanoparticles, nanosheet and nanodiamond have been developed. Now a days, inhaled CO (iCO) and hybrid carbon monoxide-releasing molecules (HYCOs) are also used in the therapy of CO. CORM can control the release of CO to a target site, this potential of CO-releasing molecules (CO-RMs) can be useful to formulate CO-based pharmaceuticals This article highlights characteristics of CO-releasing molecules (CO-RMs) and various mechanisms intricated in the therapy of CO when administered in the form of CO-RMs.

Cytotoxicity, Carbonmonoxide releasing molecules (CO-RM), Therapy, Target sites

"An overview on usage of CO-releasing molecule (CORM) as diverse pharmacological agent. ", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.10, Issue 7, page no.j670-j676, July-2023, Available :http://www.jetir.org/papers/JETIR2307983.pdf

"An overview on usage of CO-releasing molecule (CORM) as diverse pharmacological agent. ", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.10, Issue 7, page no. ppj670-j676, July-2023, Available at : http://www.jetir.org/papers/JETIR2307983.pdf