• Abdul Wahid khan
• Faisal khan
• Abdullah Taimoor Ansari
• Saeed Chowdhry
• Fuzail Ansari

People present in the society especially youngsters chew various kind of gum base which are available in different flavors and different brand. Medicated chewing gum is nothing but a gum base which contain API for treatment for certain type of disease. Due to chewing result in drug release from the chewing which get mix1 into the saliva and get penetrate into the mucosa hence increase bioavailability of drug as the release of drug by pass hepatic metabolism and also prevented from gastric degradation. As the buccal cavity is highly vascularized so, concentration of drug achieved in systemic circulation occur frequently. The release of drug from the chewing gum is directly proportional to mastication and time of chewing gum placed in mouth2.In contrast, medication produced from medicated chewing gum that is not absorbed via the membrane of the oral cavity will be ingested and arrive in the stomach in a very fine dispersed form, making it easily available for gastrointestinal absorption with a resulting rapid beginning of action. Dose given in medicated chewing gum is less as compared to conventional dosage form

Medicated Chewing gum, Polyvinyl Pyrrolidine (PVP), Eudragit EPO, Franz Diffusion Cell, Magnetic Stirrer, punching machine

"Formulation and Evaluation of Layered Chewing gum Tablet Containing Doxylamine Succinate", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.10, Issue 8, page no.e643-e652, August-2023, Available :http://www.jetir.org/papers/JETIR2308475.pdf

"Formulation and Evaluation of Layered Chewing gum Tablet Containing Doxylamine Succinate", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.10, Issue 8, page no. ppe643-e652, August-2023, Available at : http://www.jetir.org/papers/JETIR2308475.pdf