• M.R. Bhamuni
• S.R. Jayapradha*

This paper aims to synthesis curcumin based heterocyclic moiety because curcumin extracted from turmeric which is a naturally yellow colored compound has many applications in antibacterial activities. A new series of 4,4'-((1E,1'E)-(1-cinnamyl-1H-pyrazole-3,5-diyl)bis(ethene-2,1-diyl))bis(2-methoxyphenol) compound was developed from freshly prepared (E)-((E)-3-phenylallylidene)hydrazine derivative and commercially available curcumin under reflux for certain hours in presence of glacial acetic acid. The structure of the synthesized heterocyclic compound was characterized with the help of various techniques such as 1H, 13C NMR spectra, X-ray analysis, UV-Visible and FT-IR spectroscopy. This curcumin-based pyrazole derivative could also be evaluated for antibacterial activity against gram-positive and gram-negative bacteria with the zone of inhibition ranging between 15-20mm.

Curcumin, Cinnamaldehyde, Hydrazine, Pyrazole derivatives, Antibacterial activity

"SYNTHESIS OF CURCUMIN BASED 4,4'-((1E,1'E)-(1-CINNAMYL-1H-PYRAZOLE-3,5-DIYL)BIS(ETHENE-2,1-DIYL))BIS(2-METHOXYPHENOL) DERIVATIVE AND THEIR ANTIBACTERIAL ACTIVITIES", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.10, Issue 9, page no.e229-e234, September-2023, Available :http://www.jetir.org/papers/JETIR2309426.pdf

"SYNTHESIS OF CURCUMIN BASED 4,4'-((1E,1'E)-(1-CINNAMYL-1H-PYRAZOLE-3,5-DIYL)BIS(ETHENE-2,1-DIYL))BIS(2-METHOXYPHENOL) DERIVATIVE AND THEIR ANTIBACTERIAL ACTIVITIES", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.10, Issue 9, page no. ppe229-e234, September-2023, Available at : http://www.jetir.org/papers/JETIR2309426.pdf