• Suman Pattanayak
• Tripti Naskar
• Lakshmi Kanta Kanthal
• Arnab maity

The purpose of this study was to evaluate different novel drug delivery system (NDDS) i,e liposome , noisome, nanoparticle etc. . The NDDS are compared by their physiochemical characteristics, storage stability, surface charge. The diameter and surface charge of the NDDSs are comparable with previously reported injectable nanocarriers. The NDDSs showed good encapsulation efficiency and drug loading. Moreover, the NDDSs were stable during storage and in fetal bovine serum for extended periods, showed low complement consumption and were non-toxic to high concentrations. Due to less pronounced burst effect and extended release characteristics, the nano capsules could be favorable approaches for achieving prolonged pharmacological activity of AG using injectable NDDS. To perform drug polymer compatibility FT-IR studies were carried out and observed that there was no interaction between the APl and excipients.Prepared formulations are characterized by vesicle size, shape, surface charge, entrapment efficiency, drug content and invitro drug release studies. The vesicle size, size distribution and zeta potential of the optimized formulation is found to be 65.6 nm and zeta potential is found to be -1.5mV.Size distribution curve confirms the normal size distribution of the vesicles. The % entrapment efficiency of vesicles formulations were found to be in the range of 54.18±0.59 to 92.71±0.56 and optimized formulation is found to be 92.71±0.56 and drug content of noisome formulations. Thus the novel drug delivery systems (NDDS)are carriers which maintain the drug concentration in therapeutic range for longer period of time and also, in addition, may deliver the content to the site of action if so desired as per requirements

"EVALUATION OF FORMULATION OF NOVEL DRUG DELIVERYSYSTEM- A REVIEW", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.10, Issue 9, page no.e389-e399, September-2023, Available :http://www.jetir.org/papers/JETIR2309447.pdf

"EVALUATION OF FORMULATION OF NOVEL DRUG DELIVERYSYSTEM- A REVIEW", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.10, Issue 9, page no. ppe389-e399, September-2023, Available at : http://www.jetir.org/papers/JETIR2309447.pdf