• Mr. Mohammad Zishan Ibrahim
• Hake Bhima Shiwaji
• Mr. Ganesh Chandrakant Kanwate
• Narwade Mamta Madhav
• Dr. Jameel Ahmed

The aim of this research work was to develop oro-dispersible films of Bilastine, with the goal of achieving a fast onset of action to improve the management of allergic rhinitis. Using the solvent-casting method, six batches were formulated of oro-dispersible films, by using HPMC K4M, HPMC K100 as film-forming polymers. Various evaluation parameters such as thickness, weight variations, folding endurance, surface pH, disintegration, drug content, and in-vitro drug release were evaluated for all formulated batches. Among the formulated variations, F2 exhibited exceptional characteristics, lower disintegration time of only 18 seconds. Moreover, it demonstrated the highest drug release, with an impressive 95.32% of the drug being released within just 30 minutes, surpassing the performance of the other formulations. Thus, F2 was selected as the optimized formulation. Analysis through FTIR indicated that there were no significant interactions between the drug and the polymers used in the optimized formulation. In conclusion, the development of oro-dispersible film of Bilastine represents a promising approach for the treatment of allergic rhinitis. These films offer the advantage of rapid dissolution, leading to enhanced therapeutic efficacy.

Mouth Dissolving Films, Bilastine, Allergic rhinitis

"Development and Characterization of Oro Dispersible Films of Bilastine ", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.11, Issue 2, page no.d809-d816, February-2024, Available :http://www.jetir.org/papers/JETIR2402399.pdf

"Development and Characterization of Oro Dispersible Films of Bilastine ", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.11, Issue 2, page no. ppd809-d816, February-2024, Available at : http://www.jetir.org/papers/JETIR2402399.pdf