• M. Deepika
• SK. Sushma Taj
• K. Jahnavi
• B. Jeshma Kalyani
• K. Navaneetha

Organ-on-a-chip (OOAC) is a physiological organ biomimetic system constructed on a microfluidic chip and it is listed among the top 10 emerging technologies. The microenvironment of the chip mimics the organ in terms of tissue interactions and mechanical stimulation by combining cell biology, engineering and biomaterial technologies. This reflects the composition and functionality of human tissue and forecasts how the body will react to a wide range of stimuli, such as environmental factors and pharmacological reactions. OOAC is widely used in biological defense tactics and precision medicine. The chip is a microfluidic device that can guide and manipulate minuscule quantities of solution, ranging from pico-liters to milliliters, through a network of incredibly small microchannels. The term "organ" is more appropriate since it describes the microscopic tissues that are generated and housed in the microfluidic chips. These tissues have the ability to replicate one or more tissue-specific functions. Scientists have found that, although being far less complex than native tissues and organs, these systems may frequently function as accurate models of human physiology and illness. Organ-on-chips (OoCs) are made possible by cutting-edge in vitro technology that allows for the study of biological tissues and cells outside of the body. This is accomplished by keeping them in containers designed to maintain a biochemical and physical environment that is reasonably close to that of an in-vivo environment. This article includes the ideas behind OOAC and how it is used in drug development, physiological model building and toxicity from the viewpoint of several organs.

Organ on chip, Microfluidic cell, Stem cell on chip, Heart on chip, Lung on chip, Brain on chip.

"ORGAN ON A CHIP - A REVIEW AND ITS ROLE IN RESEARCH", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.11, Issue 2, page no.f255-f277, February-2024, Available :http://www.jetir.org/papers/JETIR2402533.pdf

"ORGAN ON A CHIP - A REVIEW AND ITS ROLE IN RESEARCH", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.11, Issue 2, page no. ppf255-f277, February-2024, Available at : http://www.jetir.org/papers/JETIR2402533.pdf