• Nancy Tiwari
• Ahtesham Ahmad

Diabetes mellitus remains a global health concern, necessitating continuous exploration of innovative approaches for its management. This review focuses on the synergistic effects of nanomaterials in combination with two potent medicinal plants, Withania somnifera (Ashwagandha) and Stevia rebaudiana, with a specific emphasis on their anti-diabetic activity. Nanotechnology has emerged as a promising avenue in pharmaceutical research, offering unique advantages such as enhanced bioavailability, targeted drug delivery, and improved therapeutic efficacy. The integration of nanomaterials with traditional herbal remedies presents an intriguing avenue for optimizing the therapeutic potential of medicinal plants. Withania somnifera, known for its adaptogenic and anti-diabetic properties, and Stevia rebaudiana, renowned for its natural sweetness and potential anti-diabetic effects, are explored in combination with various nanomaterials. This review delves into the diverse nanocarriers employed, including nanoparticles, liposomes, and nanogels, and their influence on the pharmacokinetics and bioactivity of the bioactive compounds derived from these plants. Key aspects covered in this review include the mechanisms underlying the anti-diabetic effects of Withania somnifera and Stevia rebaudiana, the role of nanocarriers in improving their solubility and stability, and the potential synergistic interactions among the constituents. Furthermore, safety considerations, bioavailability enhancements, and challenges associated with the use of nanomaterials in conjunction with herbal extracts are thoroughly discussed. The compilation of existing literature and research findings in this review provides valuable insights into the current state of knowledge regarding the combination of nanomaterials with Withania somnifera and Stevia rebaudiana for managing diabetes. This exploration may pave the way for future research avenues, ultimately contributing to the development of novel and effective anti-diabetic formulations.

Nanomaterial, Withania somnifera, Stevia rebaudiana, Anti-diabetic activity, Nanoparticles, Nanotechnology, Combination therapy, Herbal medicine, Diabetes mellitus, Medicinal plants, Nanocomposites, Bioavailability, Drug delivery, Antioxidant, Glucose metabolism, Insulin sensitivity, Phytochemicals, Therapeutic potential, nanomedicine

"IMPACT OF NANOMATERIAL IN COMBINATION WITH WITHANIA SOMINIFERA AND STEVIA REBAUDIANA ON THEIR ANTI-DIABETIC ACTIVITY: A REVIEW", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.11, Issue 2, page no.f570-f575, February-2024, Available :http://www.jetir.org/papers/JETIR2402571.pdf

"IMPACT OF NANOMATERIAL IN COMBINATION WITH WITHANIA SOMINIFERA AND STEVIA REBAUDIANA ON THEIR ANTI-DIABETIC ACTIVITY: A REVIEW", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.11, Issue 2, page no. ppf570-f575, February-2024, Available at : http://www.jetir.org/papers/JETIR2402571.pdf