• Aakash Rashid Ahwan
• Yashpal
• Yadav Shubham Rajman
• Yadav Shubham Jogendra
• Yadav Kripashankar Sabhajit, Yogendra Kumar Rajpoot, Rahul Mathur, Richa Kashiv ,Dr. Jagdish

Ivabradine is a selective and specific inhibitor of the hyperpolarization-activated, mixed sodium/potassium inward If current, which contributes importantly to SAN pacemaker activity.3 In animal studies, at therapeutic concentrations, ivabradine has had little action on other cardiac ionic currents or cardiac action potential shape. This may account for the drug’s lack of significant effects on myocardial contractility. All Marketed Tablet were found to be good without capping and chipping. Among all the 9 Marketed Tablet T9 formulation is optimized, as it shows maximum drug release at the end of 8hrs which suits the buccal drug delivery system criteria as per our studies. Post compression parameters of Ivabradine HCL were within the limits according to IP standards. Optimized formulation (T9) displayed that it follows zero order release kinetics and drug release follows non- Fickian diffusion mechanism.

Angina Pectoris, Anti Anginal, Ivabradine, Procoralan

"EVALUATION AND STUDY OF ANTI ANGINAL TABLET (IVABRADINE)", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.11, Issue 3, page no.h612-h618, March-2024, Available :http://www.jetir.org/papers/JETIR2403780.pdf

"EVALUATION AND STUDY OF ANTI ANGINAL TABLET (IVABRADINE)", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.11, Issue 3, page no. pph612-h618, March-2024, Available at : http://www.jetir.org/papers/JETIR2403780.pdf