• Ranu Yadav
• Nisha Jangde
• Atul Jagtap

Background: The liver plays vital roles essential for life. Despite the absence of reliable liver protective drugs, numerous natural medicinal preparations are utilized in the treatment of liver diseases. Objective: This study aims to explore the hepatoprotective effects of Curcuma longa methanolic extract against paracetamol-induced liver damage. Materials & Methods: Thirty rats of either sex was divided into five groups (n=6 per group). Group 1 served as the control and received a basal diet, maintained as the positive control group. Group 2 received paracetamol at a dose of 3 g/kg b. wt. Group 3 received paracetamol along with the standard drug Silymarin at a dose of 100 mg/kg. Groups 4 and 5 were treated with paracetamol along with Curcuma longa plant extracts at doses of 250 mg/kg and 500 mg/kg, respectively. Hepatoprotective potential was evaluated by measuring the levels of serum glutamic oxaloacetic transaminase (SGOT)/aspartate aminotransferase (AST) and serum glutamic-pyruvic transaminase (SGPT), along with other liver biomarkers. Histopathological changes were assessed using haematoxylin and eosin staining (HE). Result: Activities of serum alanine aminotransferase (ALT), AST, alkaline phosphatase (ALP), triglycerides (TG), bilirubin, and total protein were measured. Paracetamol exposure led to significant increases in urea, sodium, potassium, and chloride levels in rats. Moreover, it caused damage to liver structures. Pre-treatment with methanolic extract of Curcuma longa prevented severe alterations in biochemical parameters and liver structure disruptions induced by paracetamol. Conclusion: This study clearly demonstrates that pre-treatment with methanolic extract of Curcuma longa significantly attenuated physiological and histopathological alterations induced by paracetamol.

Key words: Hepatotoxicity, Paracetamol, Silymarin, Curcuma longa, SGOT, SGPT.

"Hepatoprotective Activity of Methanolic Extract from Curcuma longa Leaves against Paracetamol-Induced Liver Damage in Rats", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.11, Issue 3, page no.i258-i262, March-2024, Available :http://www.jetir.org/papers/JETIR2403830.pdf

"Hepatoprotective Activity of Methanolic Extract from Curcuma longa Leaves against Paracetamol-Induced Liver Damage in Rats", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.11, Issue 3, page no. ppi258-i262, March-2024, Available at : http://www.jetir.org/papers/JETIR2403830.pdf