• Sathish Kumar
• Rasiga

: Skin is the most extensive and diverse organs of the human body. It provides contact to the environment and protects the human body from unfavourable external factors. Atopic Dermatitis (AD) is a chronic inflammatory skin disease. It is characterized by strong itchy and inflamed skin condition with scaly plaques. The patient suffering from AD eventually develops asthma and allergic rhinitis in a process called ‘Atopic March’ (AM). The protein Thymic Stromal Lymphopoietin (TSLP) is thought to drive AD and AM. TSLP is highly expressed in human cutaneous epithelial cells. The medicinal plants are claimed to have anti-inflammatory and anti-itching properties that can be used to treat AD. The paper presents the results of the in silico docking study regarding the interactions between TSLP and the compounds from the medicinal plants like Trigonellafoenum, Rosmarinusofficinalis, Ficuscarica, Althaeae radix, Prunuspersica, Achyranthesaspera, Allium cepa, Curcuma longa, Camellia sinensis, Lycopersiconesculentum, Cannabis sativus, Oenotherabiennisand Matricaria chamomile. The compounds were analyzed for their significant interaction with the target, Absorption, Distribution, Metabolism, Excretion and Toxicology (ADMET) properties, drug-likeness using the Schrondinger software. The docking results were observed which indicates that 10 compoundswere found to be active. Among 10 compounds, thecompoundRosmarinic acid from Rosmarinusofficinalisshowed significant result with G.score of -6.28kcal/mol. The compound interacts with the residues Glutamic acid (GLU-78), Methionine (MET-28), Serine (SER-114) and Glutamine (GLN-80). This study may pave way for the future studies to predict the stability of the complexes formed and toconsider them as potential candidates to develop a drug out of them.

Atopic Dermatitis, Thymic Stromal Lymphopoietin(TSLP), In silico docking studies, ADMET properties, Rosmarinus officinalis, Rosmarinic acid.

"INSILICO ANALYSIS OF COMPOUNDS FROM MEDICINAL PLANTS AGAINST ATOPIC DERMATITIS [AD]", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.6, Issue 5, page no.1-6, May-2019, Available :http://www.jetir.org/papers/JETIRBK06001.pdf

"INSILICO ANALYSIS OF COMPOUNDS FROM MEDICINAL PLANTS AGAINST ATOPIC DERMATITIS [AD]", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.6, Issue 5, page no. pp1-6, May-2019, Available at : http://www.jetir.org/papers/JETIRBK06001.pdf