• Mahendran Radha
• Jeyabasker Suganya
• SharanyaManoharan
• Amrutha.P.Murugan
• Dhananya.S

Malaria is a life-threatening disease caused by Plasmodium parasite that are transmitted to people through the bites of infected female Anopheles mosquitoes. In 2017 there were estimated 219 million cases of malaria in 90 countries and WHO reported that malarial death reached 435000 during the same year. Thus the complexity of the malarial parasite made development of malarial vaccine a difficult task. Hence to combat the situation there is need for several research that can identify more efficient anti-malarial drugs. Medicinal plants has the ability to cure many types of infectious disease and hence the present researchers are pointing towards various plant kingdoms. Anisomeles malabarica is a traditional medicinal plant and has been used as a folk medicine for the treatment of various diseases. The pharmacological studies of Anisomeles malabarica were reported for the use of Antibacterial diseases. The 34 compounds from Anisomeles malabarica were retrieved through several journal surveys. The protein PfGST (plasmodium falciparum glutathione S-transferase) of PDB ID 1OKT is responsible for causing malaria in human. Molecular docking is performed using Argus Lab protocol for these 34 compounds against the protein PfGST. The best docking pose were identified and compared with the docking interactions of the PfGST with synthetic compounds S-Hexylglutathione and Protoporphyrin. Thus the docking results and comparative studies shows that the compounds of Anisomeles malabarica exhibit the best binding interactions than the synthetic compounds interactions.

Malaria, Anisomeles malabarica, Antibacterial, Synthetic compounds, Docking, Phytochemical.

"Molecular docking and Identification of Anisomeles derived inhibitors against Plasmodium falciparum glutathione s-transferase (PF GST) causing Malaria ", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.6, Issue 5, page no.55-60, May-2019, Available :http://www.jetir.org/papers/JETIRBK06010.pdf

"Molecular docking and Identification of Anisomeles derived inhibitors against Plasmodium falciparum glutathione s-transferase (PF GST) causing Malaria ", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.6, Issue 5, page no. pp55-60, May-2019, Available at : http://www.jetir.org/papers/JETIRBK06010.pdf