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June-2023
eISSN: 2349-5162
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Journal of Emerging Technologies and Innovative Research ( An International Scholarly Open Access Journal, Peer-reviewed, Refereed Journal )
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UGC and ISSN approved 7.95 impact factor UGC Approved Journal no 63975
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JETIRFY06017
Registration ID:
512997
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Title
Simultaneous estimation of Paracetamol, Caffeine, Phenylephrine Hydrochloride and Chlorpheniramine Maleate in pharmaceutical dosage form using High Performance Liquid Chromatography
Abstract
A simple, precise and accurate HPLC method was developed for the simultaneous estimation of Paracetamol, Caffeine, Phenylephrine Hydrochloride and Chlorpheniramine Maleate in tablet dosage form. Chromatographic separation of the four pharmaceuticals were performed on a COSMOSIL MSII ODS column (C-18, 250mm x 4.6mm x 5µm) with mobile phase containing 0.1% 1- Octane Sulphonic Acid sodium salt (pH 3.0 with Orthophosphoric acid) and Methanol in gradient mode with column oven temperature maintained at 40 °C, at flow rate of 1.0 ml/min. UV detection was performed at 272 nm with Rt of 3.68 mins, 4.81 mins, 9.45 mins, 24.45 mins for Paracetamol, Caffeine, Phenylephrine Hydrochloride and Chlorpheniramine Maleate respectively. Separation was completed within 25 mins. The method was validated for linearity, accuracy, precision, robustness, recovery and solution stability. Linearity was found to be acceptable over ranges (32.5 to 97.5 µg/ml) for Paracetamol, (75.0 to 225.0 µg/ml) for Caffeine, (25.0 to 75.0 µg/ml) for Phenylephrine Hydrochloride and (20.0 to 60.0 µg/ml) for Chlorpheniramine Maleate.
Key Words
Paracetamol, Caffeine, Phenylephrine Hydrochloride, Chlorpheniramine Maleate, HPLC, Simultaneous estimation, Tablet dosage
Cite This Article
"Simultaneous estimation of Paracetamol, Caffeine, Phenylephrine Hydrochloride and Chlorpheniramine Maleate in pharmaceutical dosage form using High Performance Liquid Chromatography", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.10, Issue 6, page no.127-138, June-2023, Available :http://www.jetir.org/papers/JETIRFY06017.pdf
ISSN
2349-5162 | Impact Factor 7.95 Calculate by Google Scholar
An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 7.95 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator
Cite This Article
"Simultaneous estimation of Paracetamol, Caffeine, Phenylephrine Hydrochloride and Chlorpheniramine Maleate in pharmaceutical dosage form using High Performance Liquid Chromatography", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.10, Issue 6, page no. pp127-138, June-2023, Available at : http://www.jetir.org/papers/JETIRFY06017.pdf
Publication Details
Published Paper ID: JETIRFY06017
Registration ID: 512997
Published In: Volume 10 | Issue 6 | Year June-2023
Page No: 127-138
Country: -, -, India .
Area: Engineering
ISSN Number: 2349-5162
Publisher: IJ Publication
Published Paper URL :: https://www.jetir.org/view?paper=JETIRFY06017
Published Paper PDF: https://www.jetir.org/papers/JETIRFY06017
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