• Gujare Vishal Sunil
• Dr. Dhirendra Babji Sanghai

The purpose of the work was to formulate and evaluate in vitro parameters of mucoadhesive metronidazole microspheres for the potential delivery of the drug to the colon. Mucoadhesive microspheres of metronidazole for colon targeting were prepared by the emulation-solvent evaporation method using span-80 as a emulsifying agent. The results of the preliminary trials indicate the drug: polymer ratio affected the characteristics of the mucoadhesive microspheres.The mucoadhesive microspheres were prepared in different drug: polymer (Metronidazole: Eudragit RL) ratio of 1:0.5, 1:1, 1:1.5, 1:2, 1:2.5, 1:3, 1:3.5. Mucoadhesion of microspheres was achieved by coating the microspheres with the 5%Chitosan solution, the resulting mucoadhesive microspheres were filled in the hard gelatin capsule shell followed by coating with Eudragit RL coating solution. The mucoadhesive microspheres were further evaluated for micromeritics study, particle size and surface characteristic, percentage drug content, encapsulation efficiency, in vitro Wash-off test for mucoadhesion and in vitro drug release study in the three different pH( 0.1 N HCL, Phosphate buffer pH 6.8 and Phosphate buffer pH 7.4) for 12 hours. The mucoadhesive microspheres were further studied for in vitro release kinetics and drug release mechanism. The best formulation batch exhibited highest drug entrapment efficiency of 86.81%, particle size of 58.9μm with almost spherical shape and free flowing properties, 70.33% of mucoadhesion after 5 hours, and followed Zero order rate release with non Fickian-Diffusion mechanism with 82.77% of drug release at the end of 12 hours.

"FORMULATION AND EVALUATION OF MICROSPHERE MUCOADHESIVE DRUG DELIVERY SYSTEM OF ANTIAMOEBIC DRUG", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.10, Issue 10, page no.d476-d525, October-2023, Available :http://www.jetir.org/papers/JETIRTHE2070.pdf

"FORMULATION AND EVALUATION OF MICROSPHERE MUCOADHESIVE DRUG DELIVERY SYSTEM OF ANTIAMOEBIC DRUG", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.10, Issue 10, page no. ppd476-d525, October-2023, Available at : http://www.jetir.org/papers/JETIRTHE2070.pdf