UGC Approved Journal no 63975(19)

ISSN: 2349-5162 | ESTD Year : 2014
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Published in:

Volume 1 Issue 7
December-2014
eISSN: 2349-5162

UGC and ISSN approved 7.95 impact factor UGC Approved Journal no 63975

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Published Paper ID:
JETIR1701242


Registration ID:
232143

Page Number

1389-1401

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Title

FORMULATION AND EVALUATION OF FAST DISSOLVING TABLETS OF SUMATRIPTAN SUCCINATE

Abstract

In this study, Fast dissolving tablets of Sumatriptan Succinate has been prepared by dry granulation to improve dissolution rate of drug in oral cavity for better patient’s compliance & effective therapy. Sumatriptan Succinate is widely used in the treatment of migraine and cluster headache. Migraine caused by temporary swelling of blood vessels in head. The main objective of this study was to formulate fast dissolving tablets of Sumatriptan succinate to achieve a better dissolution rate and further improvement in the bioavailability of the drug. It has low oral bioavailability due to first pass metabolism and incomplete absorption. Fast dissolving tablets of Sumatriptan succinate were prepared with combination of superdisintegrants like Kollidon CL (crospovidone), AC-DI-SOL (croscarmellose sodium), and Starch-1500 (Pregelatinised starch) by using the dry granulation and compression method. The all (formulations) compressed tablets were evaluated for thickness, uniformity of weight, drug content, hardness, friability, wetting time, in vitro and in vivo disintegration time, in vitro drug release and microbial evaluation. It has been evaluated that formulation batch F3 contains superdisintegrants i.e. Kollidon-CL (4%), Ac-di-sol (1.5%), which exhibit the promising results in term of enhanced dissolution rate, wetting time and disintegration time and leads to improved bioavailability, effectiveness and better patient’s compliance. In this study, Fast dissolving tablets (F1-F8) has also been subjected to microbial contamination study, as that presence of microbial flora may affect the quality, safety and efficacy of the product’s activity. It has been evaluated that the presences of total aerobic bacterial counts were found less than 100cfu while fungal colonies were found nil.ration time, in vitro drug release.

Key Words

Sumatriptan Succinate, FDTs, Dry Granulation, In-vitro & In-vivo disintegration time, in vitro drug release.

Cite This Article

"FORMULATION AND EVALUATION OF FAST DISSOLVING TABLETS OF SUMATRIPTAN SUCCINATE ", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.1, Issue 7, page no.1389-1401, December-2014, Available :http://www.jetir.org/papers/JETIR1701242.pdf

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2349-5162 | Impact Factor 7.95 Calculate by Google Scholar

An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 7.95 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator

Cite This Article

"FORMULATION AND EVALUATION OF FAST DISSOLVING TABLETS OF SUMATRIPTAN SUCCINATE ", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.1, Issue 7, page no. pp1389-1401, December-2014, Available at : http://www.jetir.org/papers/JETIR1701242.pdf

Publication Details

Published Paper ID: JETIR1701242
Registration ID: 232143
Published In: Volume 1 | Issue 7 | Year December-2014
DOI (Digital Object Identifier):
Page No: 1389-1401
Country: Meerut, Uttar Pradesh, India .
Area: Pharmacy
ISSN Number: 2349-5162
Publisher: IJ Publication


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