UGC Approved Journal no 63975(19)

ISSN: 2349-5162 | ESTD Year : 2014
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Published in:

Volume 3 Issue 4
April-2016
eISSN: 2349-5162

UGC and ISSN approved 7.95 impact factor UGC Approved Journal no 63975

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Published Paper ID:
JETIR1701768


Registration ID:
400099

Page Number

506-513

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Title

FORMULATION AND EVALUATION OF MICROEMULSION BASED INTRANASAL DRUG DELIVERY OF AGOMELATIN.

Abstract

The purpose of this study was to develop agomelatine microemulsion for intranasal delivery. Agomelatine, an antidepressant drug, has absolute bioavailability of only 5% due to high first pass metabolism. Agomelatine microemulsion were prepared by titration method. Ternary phase diagram gave the microemulsion region and the concentration of oil; Smix and water were selected from ternary phase diagram. Based on solubility study, Capmul MCM tween 80 and propylene glycol were selected as oil, surfactant and co surfactant respectively. Microemulsions were prepared using water titration method. 2:1% v/v ratio (Tween 80: Propylene glycol) was selected for formulation development. The prepared microemulsions were optimized optical transparency, viscosity measurement, phase separation, determination of pH, measurement of globule size, measurement of zeta potential, drug content, In vitro diffusion study, stability studies. The optimized batch was further characterized for optical transparency, viscosity measurement, phase separation, determination of pH, measurement of globule size, measurement of zeta potential, drug content, In vitro diffusion study, stability studies.

Key Words

Depression Agomelatin, Nose to brain

Cite This Article

"FORMULATION AND EVALUATION OF MICROEMULSION BASED INTRANASAL DRUG DELIVERY OF AGOMELATIN.", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.3, Issue 4, page no.506-513, April-2016, Available :http://www.jetir.org/papers/JETIR1701768.pdf

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2349-5162 | Impact Factor 7.95 Calculate by Google Scholar

An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 7.95 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator

Cite This Article

"FORMULATION AND EVALUATION OF MICROEMULSION BASED INTRANASAL DRUG DELIVERY OF AGOMELATIN.", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.3, Issue 4, page no. pp506-513, April-2016, Available at : http://www.jetir.org/papers/JETIR1701768.pdf

Publication Details

Published Paper ID: JETIR1701768
Registration ID: 400099
Published In: Volume 3 | Issue 4 | Year April-2016
DOI (Digital Object Identifier):
Page No: 506-513
Country: -, -, India .
Area: Engineering
ISSN Number: 2349-5162
Publisher: IJ Publication


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