• Dr. Sangeeta Kamthan

A new series of N3 – substituted 5-phenyl-1, 3, 4-thiadiazole-2-yl has been synthesized by condensation of different chloro-acetylated thiadiazole nuclei with alkali metal cyanate in presence of quaternary ammonium salt. The rate of reaction was found to be enhanced in presence of a polar solvent. The compounds were evaluated for anticonvulsant activity. Di-phenyl hydantoin sodium was used as the standard drug. Two of the compounds showed significant activity, compound V, N3–(5-p-dimethyl-amino-phenyl-1, 3, 4-thiadiazole -2-yl) hydantoin and compound II, N3 –5-(p-methoxy-phenyl-1, 3, 4-thiadiazole -2-yl) hydantoin were found to show potent activity.

epilepsy, anticonvulsant compounds, structure-activity relationship

"SYNTHESIS OF NEW N3- SUBSTITUTED THIADIAZOLE HYDANTOIN DERIVATIVES AS ACTIVE ANTIEPILEPTIC COMPOUNDS", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.3, Issue 12, page no.79-83, December-2016, Available :http://www.jetir.org/papers/JETIR1701852.pdf

"SYNTHESIS OF NEW N3- SUBSTITUTED THIADIAZOLE HYDANTOIN DERIVATIVES AS ACTIVE ANTIEPILEPTIC COMPOUNDS", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.3, Issue 12, page no. pp79-83, December-2016, Available at : http://www.jetir.org/papers/JETIR1701852.pdf