UGC Approved Journal no 63975(19)

ISSN: 2349-5162 | ESTD Year : 2014
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Volume 3 Issue 12
December-2016
eISSN: 2349-5162

UGC and ISSN approved 7.95 impact factor UGC Approved Journal no 63975

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Published Paper ID:
JETIR1701852


Registration ID:
503410

Page Number

79-83

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Title

SYNTHESIS OF NEW N3- SUBSTITUTED THIADIAZOLE HYDANTOIN DERIVATIVES AS ACTIVE ANTIEPILEPTIC COMPOUNDS

Abstract

A new series of N3 – substituted 5-phenyl-1, 3, 4-thiadiazole-2-yl has been synthesized by condensation of different chloro-acetylated thiadiazole nuclei with alkali metal cyanate in presence of quaternary ammonium salt. The rate of reaction was found to be enhanced in presence of a polar solvent. The compounds were evaluated for anticonvulsant activity. Di-phenyl hydantoin sodium was used as the standard drug. Two of the compounds showed significant activity, compound V, N3–(5-p-dimethyl-amino-phenyl-1, 3, 4-thiadiazole -2-yl) hydantoin and compound II, N3 –5-(p-methoxy-phenyl-1, 3, 4-thiadiazole -2-yl) hydantoin were found to show potent activity.

Key Words

epilepsy, anticonvulsant compounds, structure-activity relationship

Cite This Article

"SYNTHESIS OF NEW N3- SUBSTITUTED THIADIAZOLE HYDANTOIN DERIVATIVES AS ACTIVE ANTIEPILEPTIC COMPOUNDS", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.3, Issue 12, page no.79-83, December-2016, Available :http://www.jetir.org/papers/JETIR1701852.pdf

ISSN


2349-5162 | Impact Factor 7.95 Calculate by Google Scholar

An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 7.95 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator

Cite This Article

"SYNTHESIS OF NEW N3- SUBSTITUTED THIADIAZOLE HYDANTOIN DERIVATIVES AS ACTIVE ANTIEPILEPTIC COMPOUNDS", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.3, Issue 12, page no. pp79-83, December-2016, Available at : http://www.jetir.org/papers/JETIR1701852.pdf

Publication Details

Published Paper ID: JETIR1701852
Registration ID: 503410
Published In: Volume 3 | Issue 12 | Year December-2016
DOI (Digital Object Identifier):
Page No: 79-83
Country: -, -, India .
Area: Engineering
ISSN Number: 2349-5162
Publisher: IJ Publication


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