• Dr. Tathagata Chakraborty

Regulatory T (Treg) cells can be defined as a T-cell population that functionally suppresses an immune response by influencing the activity of another cell type (Shevach, 2004) and thereby maintain immune system homeostasis and tolerance to self. However, recent advances in the molecular characterization of this cell population have firmly established their existence and their critical role in the vertebrate immune system (Sakaguchi et al., 1995). Interest in Treg cells has been heightened by evidence from experimental mouse models demonstrating that the immunosuppressive potential of these cells can be harnessed therapeutically to treat autoimmune diseases and facilitate transplantation tolerance. If Treg cells are specifically eliminated that potentiate cancer immunotherapy (Sakaguchi, 2005). Treg cells are thought to dampen T-cell immunity to tumour-associated antigens and to be the main obstacle tempering successful immunotherapy and active vaccination (Zou, 2006).

Role of Regulatory T cells in immunomodulation: A review

"Role of Regulatory T cells in immunomodulation: A review", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.2, Issue 9, page no.549-558, April-2016, Available :http://www.jetir.org/papers/JETIR1701928.pdf

"Role of Regulatory T cells in immunomodulation: A review", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.2, Issue 9, page no. pp549-558, April-2016, Available at : http://www.jetir.org/papers/JETIR1701928.pdf