• Jagpal Singh
• Mahendra Singh

This research focuses on the development of a novel drug delivery system to enhance the oral bioavailability of Famotidine, a poorly water-soluble and permeable drug. Solid Lipid Nanoparticles (SLNs) were prepared using the ultrasonic-hot emulsification technique to encapsulate Famotidine effectively. The SLNs' formulation comprised a mixture of glycerol monostearate (GMS) and span 20 (in a 3:1 w/w ratio), which were melted at approximately 60 °C. Famotidine was then incorporated into the melted lipid mixture at a concentration of 2 mg/mL of the total volume. Aqueous phase containing poloxamer (4 mg/mL) was heated to a similar temperature and added to the lipid mixture, followed by thorough mixing using a high-shear homogenizer (T25 Ultraturax, IKA) and subsequent sonication with a probe sonicator (Misonix) to achieve stable emulsion.

Famotidine; Bioavailability; Solid lipid nanoparticle; Oral absorption; Poorly aqueous-soluble drug

"Formulation Process of Solid lipid Nanoparticles improves oral bioavailability of Drug Famotidine", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.3, Issue 1, page no.923-930, January-2016, Available :http://www.jetir.org/papers/JETIR1701983.pdf

"Formulation Process of Solid lipid Nanoparticles improves oral bioavailability of Drug Famotidine", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.3, Issue 1, page no. pp923-930, January-2016, Available at : http://www.jetir.org/papers/JETIR1701983.pdf