• Shivakumara K N

Novel peptide conjugates with a piperazinyl group were produced by combining shorter peptides with benzylpiperazine using IBCF as the coupling agent, HOBt, and NMM as the base at ±15 0C. Initially, the process involved stirring the mixture at ±15 0C for 2 hours, followed by an overnight reaction. The resulting compounds were identified using 1H NMR and Rf values, and then tested for antibacterial effects against Staphylococcus aureus, Escherichia coli, Klebsiella pnemoniae, and Pseudomonas aeruginosa, as well as antifungal effects against Aspergillus Niger, Aspergillus flavus, and Fusarium monoliforme. XXI displayed notable activity among the compounds synthesized, whereas XIX and XX showed moderate activity.

Peptide conjugates, Zone of inhibition, drug delivery, Piperazine and selectivity.

"Synthesis of piperazinylpeptide conjugates containing smaller peptide molecules as a promising avenue for the development of new antimicrobial agents", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.3, Issue 9, page no.379-385, September 2016, Available :http://www.jetir.org/papers/JETIR1701B57.pdf

"Synthesis of piperazinylpeptide conjugates containing smaller peptide molecules as a promising avenue for the development of new antimicrobial agents", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.3, Issue 9, page no. pp379-385, September 2016, Available at : http://www.jetir.org/papers/JETIR1701B57.pdf