• Vishal Tulsidas Chudasama

Increasing strain of microorganism with resistance is an alarming danger in current therapeutic era. WHO is giving red signal towards half hazard use of anti-microbials. Emergence of Mycobacterium producing MDR/RR-TB, XDR-TB are rising day by day. Discovery of newer molecule have been a fascinating and challenging task for researcher. Based on pharmacophore requirement for initial binding sites for antibacterial agent and basic structural requirement for various heterocycles a series of substituted pyrimidine 2-amino-5-cyano-4-hydroxy-6-(alkyl/aryl amino)pyrimidine have been synthesized. 2 component method for synthesis of pyrimidine was employed in which Condensation of Different cyanoketene S, N acetal with guanidine nitrate in presence of Sodium ethoxide yielded the designed series of substituted pyrimidines. All synthesized compounds were characterised by physical and spectral analysis. All were screened for antibacterial activity by cup-plate method against gram positive and gram-negative microorganism and zone of inhibition was compared to standard drug ciprofloxacin.

Pyrimidine, Antibacterial

"Design, Synthesis and Evaluation of 2-amino-5-cyano-4-hydroxy-6-(alkyl/aryl amino)pyrimidine as Potential Antibacterial Agents.", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.3, Issue 1, page no.635-641, January-2016, Available :http://www.jetir.org/papers/JETIR1701B97.pdf

"Design, Synthesis and Evaluation of 2-amino-5-cyano-4-hydroxy-6-(alkyl/aryl amino)pyrimidine as Potential Antibacterial Agents.", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.3, Issue 1, page no. pp635-641, January-2016, Available at : http://www.jetir.org/papers/JETIR1701B97.pdf