• Dr. Sunita Jain

Wogonin, 5,7-dihydroxy-8-methoxyflavone, extracted from Holmskioldia sanguinen Retz. has been tested for oestrogenic and anti-implantational activities in the rat. Wogonin displayed mild oestrogenic but effective anti-implantational activities. In the three days uterotrophic bioassay, at a dose level of 10 mg/kg body weight per day, intramuscularly, the wet uterine and vaginal weights increased significantly. Wogonin at the xame dose level when given intramuscularly from days 1-3, 4-6, 1-7 post coitum and orally from days 1-7 pou coitum effectively inhibited implantation. However, when the drug was administered from days 7-9 post coitum, it did not affect the implantation but interfered with normal development of the embryos which resulted in the resorption of foetuses. Wogonin. mild oestrogenic compound, exhibited interceptory activity at all the stages of pregnancy.

Holmskioldia; flavone; wogonin; antifertility; anti-implantation in the rat.

"Wogonin, Wogonin, 5,7-dihydroxy-8-methoxyflavone as Oestrogenic and Anti-implantational Agent in the Rat", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.2, Issue 1, page no.777-781, January 2015, Available :http://www.jetir.org/papers/JETIR1701D62.pdf

"Wogonin, Wogonin, 5,7-dihydroxy-8-methoxyflavone as Oestrogenic and Anti-implantational Agent in the Rat", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.2, Issue 1, page no. pp777-781, January 2015, Available at : http://www.jetir.org/papers/JETIR1701D62.pdf