• Shailendra Kumar
• Preety Sinha

Arsenic is noxious metalloid that subsist everywhere in the surrounding and disturb worldwide health issue due to its carcinogenicity. Progressive increase of arsenic-related diseases and various types of cancer incidences were reported for the last few years in Bihar. Our work has focused on the toxic effects of arsenic exposure in the blood of mice and women. Female Swiss albino mice were selected as the experimental animals. In the treatment group 1.8 mg/kg body weight sodium arsenite and in control group distilled water was given orally by gavage method daily for 1 month, 2 months, 3 months, 4 months and 5 months. After the treatment of mice, blood samples were collected. Normal women and arsenic exposed ovarian cancer patients from arsenic affected districts of Bihar were selected as human model and blood samples were collected with their prior consent of the subjects. The levels of sodium arsenite of blood of all arsenic treated mice groups were significantly (p < 0.05 for Group A and for rest of the Groups, p < 0.01) higher than that of the control mice group. The arsenic levels were significantly (p < 0.05 for Bhagalpur district and for rest all districts p < 0.01) higher in ovarian cancer patients from all sample districts as compared to the normal group of women. Thus, the present work reveals the toxic effect of arsenic exposure in the blood of Swiss albino mice and women of arsenic hit districts of Bihar.

Sodium Arsenite, Swiss Albino Mice, Blood, Ovarian Cancer Patients.

"Comparative Analysis of Arsenic Levels in the Blood of Arsenic Induced Female Mice and Its Correlation with Ovarian Cancer Patients", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.4, Issue 5, page no.448-452, May-2017, Available :http://www.jetir.org/papers/JETIR1705081.pdf

"Comparative Analysis of Arsenic Levels in the Blood of Arsenic Induced Female Mice and Its Correlation with Ovarian Cancer Patients", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.4, Issue 5, page no. pp448-452, May-2017, Available at : http://www.jetir.org/papers/JETIR1705081.pdf