• Renu Kumari Sinha
• Manish Chandra Varma

A significant role of Carica papaya aqueous leaf extract was observed in the liver of hyperglycemic swiss albino mice under surface electron microscopic examination. Diabetic mice treated with aqueous leaf extract of Carica papaya for 56 days at one time dose of 150 mg/kg body weight for orally daily. The total dose of Alloxan monohydrate (450 mg kgˉ¹ bwˉ¹) was administrated in three injections at interval of 48 hrs (150 mg kgˉ¹ bwˉ¹) each time. Mice with blood glucose level of greater than 200 mg/dl were considered diabetic and were selected for study. Remarkable changes that occurred in the liver of diabetic mice verses control mice. These changes include degenerative alteration represented by disorganization of the hepatic cords, vacuolated hepatocytes, cytoplasmic vacuolization and picnotic nuclei of hepatocytes and inflammatory cell infiltration.

Hyperglycemic, Alloxan monohydrate, Carica papaya leaf, Aqueous extract, Scanning electron microscope

"Ultrastructural alteration in liver of diabetic mice and repaired by aqueous leaf extract of Carica papaya ", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.4, Issue 6, page no.523-525, June-2017, Available :http://www.jetir.org/papers/JETIR1706098.pdf

"Ultrastructural alteration in liver of diabetic mice and repaired by aqueous leaf extract of Carica papaya ", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.4, Issue 6, page no. pp523-525, June-2017, Available at : http://www.jetir.org/papers/JETIR1706098.pdf