• Ahtisham Wafai
• Asrar H. Wafai
• Asif Amin
• Xu Jian Zhong

Purpose: To investigate the effect of application of Tranexamic acid just prior to tourniquet deflation on postoperative D-dimer levels of Total Knee Arthroplasty patients so as to allow precise prediction of DVT and PE. Method: A total of 40 patients were identified to undergo primary unilateral total knee arthroplasty. One group of patients received tranexamic acid and second group of patients received a similar volume of normal saline, just before the deflation of the tourniquet. All patients were screened for coagulation parameters before and 24 hours after the surgery. Then the post-operative levels of coagulation parameters of Tranexamic acid group and control group were compared in order to evaluate the effect of Tranexamic acid on these variables. Results The two groups were comparable in pre-operative concentrations of D-dimer levels. The difference between the post-operative D-dimer levels of two groups were statistically significant (p < 0.05). D-dimer levels in control group were on the higher side (p<0.05) when compared to the TXA group. There were no significant differences in the post-operative values of fibrinogen levels, prothrombin time,thrombin time and activated partial thromboplastin time between the two groups（p>0.05). Conclusion The administration of TXA in TKA reduces plasma D- dimer levels and hence reduces the chances of DVT and PE.

Total Knee Arthroplasty (TKA),Tranexamic acid (TXA), D-dimer, Deep venous thrombosis (DVT), Pulmonary embolism (PE)

"Administration of Tranexamic acid in Total Knee Arthoplasty does not increase the risk of Deep vein Thrombosis and Pulmonary Embolism ", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.4, Issue 11, page no.253-258, November-2017, Available :http://www.jetir.org/papers/JETIR1711048.pdf

"Administration of Tranexamic acid in Total Knee Arthoplasty does not increase the risk of Deep vein Thrombosis and Pulmonary Embolism ", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.4, Issue 11, page no. pp253-258, November-2017, Available at : http://www.jetir.org/papers/JETIR1711048.pdf