UGC Approved Journal no 63975(19)

ISSN: 2349-5162 | ESTD Year : 2014
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Published in:

Volume 5 Issue 4
April-2018
eISSN: 2349-5162

UGC and ISSN approved 7.95 impact factor UGC Approved Journal no 63975

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Published Paper ID:
JETIR1804381


Registration ID:
236206

Page Number

943-959

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Title

Transition Metal based Anticancer drug : A Review on Current Cancer Chemotherapy Drugs.

Abstract

Chemotherapy is one of the most common treatments for cancer. It uses certain drugs to kill cancer cells or to stop them from growing and spreading to other parts of your body. Your doctor might prescribe chemo by itself or with surgery or radiation therapy.More than 50 percent of cancer patients are treated with platinum complexes viz cisplatin, carboplatin and oxaliplatin. Cisplatin; cis-Diamminedichloroplatinum (II), the best chemotherapeutic agents is frequently used in the treatment of various types of cancers like sarcomas, carcinomas, lymphomas and germ cell tumors. Mode of action of cisplatin is related to its ability to form 1, 2 - intrastrand crosslink with DNA nucleotide. Clinically, the complexes of platinum are used as adjunct therapy in cancers that directly focuses to induce cell apoptosis. Platinum based drugs are like the backbone of metallo drugs as they can damage DNA by interfering with DNA repair mechanisms which induces apoptosis in cancer cells. This review mainly discuss about the chemotherapeutic properties of cisplatin and other platinum drugs in the treatment of various human cancers. Deep understanding of mechanisms of action of anticancer agents might lead to develop more efficient and well organized platinum antitumor drugs and therapeutically provide new opportunities in cancer treatment. Extensive research is underway to understand the role of metal complexes in cancer treatment.

Key Words

Cancer, DNA, platinum, metal complexes, apoptosis, selective target.

Cite This Article

"Transition Metal based Anticancer drug : A Review on Current Cancer Chemotherapy Drugs.", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.5, Issue 4, page no.943-959, April-2018, Available :http://www.jetir.org/papers/JETIR1804381.pdf

ISSN


2349-5162 | Impact Factor 7.95 Calculate by Google Scholar

An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 7.95 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator

Cite This Article

"Transition Metal based Anticancer drug : A Review on Current Cancer Chemotherapy Drugs.", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.5, Issue 4, page no. pp943-959, April-2018, Available at : http://www.jetir.org/papers/JETIR1804381.pdf

Publication Details

Published Paper ID: JETIR1804381
Registration ID: 236206
Published In: Volume 5 | Issue 4 | Year April-2018
DOI (Digital Object Identifier):
Page No: 943-959
Country: -, -, - .
Area: Engineering
ISSN Number: 2349-5162
Publisher: IJ Publication


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