• Diksha Singh
• Mayank Srivastava
• Pallavi Tiwari
• Saurav Ghoshal

: The present study was conducted to evaluate the hepatoprotective action extract of Holoptelea integrifolia against paracetamol induced liver damage in rats. To evaluate the hepatoprotective action of Holoptelea integrifolia Wistar albino male rats weighing between 150-200 gm were used. Rats were divided into six groups (each contains six animals). Group 1 served as normal control received 1% tween 80 (1ml/kg). Group 2 served as Hepatotoxic control received paracetamol 2g/kg body weight. Group 3 served as standard control received silymarin 100mg/kg and paracetamol on 3rd day and Group 4,5 and 6 received methanolic extract of Holoptelea integrifolia150mg/kg, 300mg/kg and 450 mg/kg respectively and paracetamol on 3rd day. At the end on day 5th blood sample was collected by heart puncturing method for the estimation of markers like ALT, AST, ALP, Total bilirubin and total protein. Liver was isolated for histopathological estimation. From the result it was concluded that methanolic extract of Holoptelea integrifolia at the dose of 450mg/kg is effective and shows significant decrease in the level of ALT, AST, ALP, total bilirubin.

Hepatoprotective, Holoptelea integrifolia, Histopathology, Paracetamol, Silymarin.

"Hepatoprotective Action of Methanol Extract of Stem of Holoptelea integrifolia Planch. against Paracetamol Induced Hepatotoxicity in Wistar Albino Rats", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.5, Issue 6, page no.418-426, June-2018, Available :http://www.jetir.org/papers/JETIR1806182.pdf

"Hepatoprotective Action of Methanol Extract of Stem of Holoptelea integrifolia Planch. against Paracetamol Induced Hepatotoxicity in Wistar Albino Rats", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.5, Issue 6, page no. pp418-426, June-2018, Available at : http://www.jetir.org/papers/JETIR1806182.pdf