• suprabha devi
• vikram singh
• raj prasad
• manoj kumar mishra

In traditional medicinal trees, D. sissoo is a popular species around the world.In very larg numbers distribution in different parts of India. Dalbergia sissoo is uses for medicine purpose from many of years and now theire growing demand for natural based medicines, marketed products, pharma industries and cosmetics. D.sissoo is hugely growing plant which is using traditionally as anti-inflammatory, antipyretic, analgesic, anti-oxidants, anti-diabetic and as antimicrobial agent. Many chemical constituents have been isolated and sflavanols, tannins, saponins, steroids and terpenoids, carbohydrates. Compounds isolated from D.sissoo like an isoflavone, biochanin is a essential therapeutic cancer preventive agent with a different estrogenic property. D.sissoo have numaral pharmacological properties however, it is necessary that numbers of clinical and pharmacological studies should be done to determine the undeveloped potency of the plant. The present research was goal to determine the effective hepato-protective activity of ethanol extracts of leaves of D.sissoo using in vivo paracetamol hepatotoxicity models to evaluate the superstistious use of the plant. The hepato-protective activity of the ethanol extracts of leaves were studied on male albino wistar rats, liver toxication produce by acetylaminophenol (2.0 gm/kg, p.o.) by determining biochemicals. Number of biochemicals parameters were studied to determine the hepatoprotective property of ethanol extracts in serum like glutamic pyruvic transaminase ( SGPT ), serum glutamic oxaloacetic transaminase (SGOT), and serum alkaline phosphatase ( SALP) , total bilirubin (SB), total protein, and histopathologies in liver were also studied compare with silymarin ( 100mg/kg, p.o.) as standard hepatoprotective agents were determined to assess the effect of the ethanol extract of leaves of Dalbergia sissoo ( 100 and 200 mg/kg) on the acetylaminophenol produce hepatic toxication. The phytochemical determination of the extracts showed presence of Biochanin A, tectoregenin, carbohydrates, proteins, amino acids, tannins compounds, and flavanoids. Pre-treatment of the rats with ethanol extract subjected to acetylaminophenol administration caused a remarkably decrease in the values of SGOT ,SGPT , ALP, and SB almost comparable to the silymarin . The hepatoprotective was proved by histopathologic study of the liver tissues of control group and ethanolic extract treat animal group. The results indicate that this plant possesses potential hepatoprotective properties and has therapeutic potential for the treatment of liver diseases.

: Dalbergia sissoo Linn. Paracetamol(acetylaminophenol); hepatoprotective activity; silymarin; histopathology.

"Hepatoprotective Activity of Dalbergia sissoo Leaves Ethanolic Extract Against Paracetamol Induced Liver Toxicity in Rat", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.5, Issue 6, page no.754-763, June-2018, Available :http://www.jetir.org/papers/JETIR1806231.pdf

"Hepatoprotective Activity of Dalbergia sissoo Leaves Ethanolic Extract Against Paracetamol Induced Liver Toxicity in Rat", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.5, Issue 6, page no. pp754-763, June-2018, Available at : http://www.jetir.org/papers/JETIR1806231.pdf