• Ganesh Kumar
• Anjali Joshi
• Preeti Kothiyal

In the current research, Fast dissolving thin strips (FDTS) of Venlafaxine hydrochloride was formulated for the treatment of depression. Depression is considered as a common mental disorder which is generally recognized by depressed mood, low energy level, disturbance in sleep and appetite, weak concentration level, feelings of guilt etc.. The objective is to formulate FDTS of Venlafaxine to overcome the problem of dysphagia and decreased bioavailability bypassing hepatic metabolism. FDTS dissolve or disintegrate in mouth when they came in contact with saliva, as the oral mucosa is highly vascularised so drug directly enter into systemic circulation and provide quick onset of action and instant bioavailability. The FDTS of Venlafaxine were prepared by solvent casting method by using hydrophilic polymers HPMC K4M and Poly Vinyl alcohol , superdisintegrant like crosspovidone, cross carmellose sodium and sodium starch glycolate, plasticizer PEG-400, sweetening agent, saliva stimulating agent etc. The prepared FDTS were evaluated for Surface texture, Appearance, transparency, Weight variation and its value was found within range, Film thickness (0.169 ±0.0077 to 0.192 ±0.0025), Tensile strength (1.62±0.51 to 1.69±0.23), Percent elongation (24±0.89 to 30±0.36), Folding endurance (256±6.11 to 276±8.02), Surface pH (6.35±0.126 to 6.56±0.132), % Moisture uptake (1.82±0.339 to 2.23±0.458), % Moisture loss (1.41±0.462 to 2.39±0.237) % Drug content (94.75 ±0.010 to 97.74±0.031), Disintegration test(12±0.143sec. to 16±0.743sec.), In-vitro dissolution test (92.56 to 97.32). It was evaluated that different superdisintegrant has significant effect on disintegration time, dissolution rate and permeation rate of FDTS of Venlafaxine. From above experimental study it was concluded that FDTS were successfully prepared and evaluated. Prepared formulation are capable to deliver venlafaxine at a rate and extent that may improve its therapeutic effectiveness hence improve patient compliance.

Venlafaxine HCl, Fast dissolving thin strips (FDTS), Dysphagia, Bioavailability, Solvent casting technique.

"FORMULATION AND EVALUATION OF FAST DISSOLVING THIN STRIPS OF VENLAFAXINE HYDROCHLORIDE", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.5, Issue 7, page no.31-41, July-2018, Available :http://www.jetir.org/papers/JETIR1807475.pdf

"FORMULATION AND EVALUATION OF FAST DISSOLVING THIN STRIPS OF VENLAFAXINE HYDROCHLORIDE", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.5, Issue 7, page no. pp31-41, July-2018, Available at : http://www.jetir.org/papers/JETIR1807475.pdf