• G.Gnanarajan
• Himanshi Rathaur
• Preeti Kothiyal

The aim of the present research was to formulate and evaluate sublingual tablet of Olanzapine by reducing first pass ratio, increasing bioavailability and improve patient compliance, belonging to the class of thienobenzodiazepine, atypical anti-psychotics drug which is a first line psychiatrics treatment for schizophrenia. The sublingual tablets were prepared by direct compression method using different superdisintegrant like Croscarmellose Sodium, Crospovidone, and Sodium starch glycolate in different ratio. The pre-compression parameters of powder and post-compression parameters of prepared sublingual tablets were evaluated. Post-compression parameters like appearance, weight variation, Hardness, thickness, friability, drug content, disintegration time, wetting time, water absorption ratio, in-vitro dispersion time and in-vitro drug release studies. It was observed that post-compression parameters like weight variation, Hardness, friability and drug content was found within the Standard limits as per described in I.P. The formulation F6 with 5% crospovidone as superdisntegrant showed faster disintegration time of 24.1±0.37 sec and lower the wetting time of 27.3±0.47 sec i.e lower the wetting time, quicker the disintegration time. It was observed that concentration of superdisintegrant has significant effect on the disintegration time of olanzapine tablet formulation. Higher the concentration of superdisintegrant used, the shorter the time required for the tablet to disintegrate. In-vitro drug release studies were performed by using pH 6.8 phosphate buffer used as a dissolution medium, F6 showed 95.36% drug release within the time interval of 15 min. The release kinetic study revealed that formulation F6 showed fickian release of mechanism and showed first order kinetic. Formulation F6 showed the best result as the disintegration time required was less as compared to other formulation. Thus, it was concluded that this study can be beneficial for the formulation of sublingual tablets of olanzapine and was successfully formulated by adding different type of superdisintegrants with improved patient compliance and bioavailability of the drug which bypasses the hepatic metabolism.

Anti-psychotic, Schizophrenia, Sublingual, Olanzapine

"FORMULATION AND EVALUATION OF SUBLINGUAL TABLET OF OLANZAPINE", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.5, Issue 7, page no.68-81, July-2018, Available :http://www.jetir.org/papers/JETIR1807479.pdf

"FORMULATION AND EVALUATION OF SUBLINGUAL TABLET OF OLANZAPINE", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.5, Issue 7, page no. pp68-81, July-2018, Available at : http://www.jetir.org/papers/JETIR1807479.pdf