• Parul Bisht
• Archana Gahtori

Forensic science deals with every aspect of science for the criminal justice system. Selection of instrument or techniques or even method should be critically judged to give accurate conclusions. In recent years, hyphenated techniques have been in trend for their advantage to perform a combined function. One such technique is LC-MS. These hyphenated techniques have proven to be a boon in the world of science. In the survey we found that new sample preparation techniques were utilized to concentrate the analyte present in the sample and to remove the interfering matrix element. This review article provides analytical data such as analyte under examination, sample preparation technique, percentage recovery, LOQ of analytes for biological samples of urine, blood, hair, plasma, serum, fetal postmortem brain in Forensic toxicology. The analyte under examination were drugs like cocaine, opiates, hallucinogens, amphetamine, cannabinoids, antipsychotics, and the tricyclic.

Liquid chromatography- Mass spectrometry, Forensic Toxicology, Sample Preparation, Drug of Abuse.

"A REVIEW ON LIQUID CHROMATOGRAPHY-MASS SPECTROSCOPY: A MAJOR TOOL IN ANALYZING FORENSIC SAMPLES", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.5, Issue 7, page no.236-249, July-2018, Available :http://www.jetir.org/papers/JETIR1807501.pdf

"A REVIEW ON LIQUID CHROMATOGRAPHY-MASS SPECTROSCOPY: A MAJOR TOOL IN ANALYZING FORENSIC SAMPLES", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.5, Issue 7, page no. pp236-249, July-2018, Available at : http://www.jetir.org/papers/JETIR1807501.pdf