• Ganesh Kumar
• Bharti Lohani
• Preety Kotiyal

In the present research a medicated nail lacquer of Butenafine HCl had been developed for the treatment of paronychia. The main aim of the study was to provide a medicament over the nail for an extended period of time. The FTIR study was revealed that drug and all excipients are compatible.The antifungal activity of prepared nail lacquer was calculated against candida albicans & zone of inhibition was calculated by comparing with marketed cream. In this study demonstrating the effect of different penetration enhancer’s like- thioglycolic acid, urea (H2O2) and 2-mercaptoethanol by ex-vivo permeation study. In the prepared nail lacquer penetration enhancers mainly act by breaking disulphide bond of the nail.The ex vivo permability studywas carry out on goat hooves in the franz diffusion cell using phosphate buffer 7.4 as a medium.The formulation containing 1.5 gm of ethyl cellulose , along with 0.5 ml of thioglycolic acid showing the highest release(85.64%) and the formulation showing first order release kinetics and Super case II transport mechanism.

Transungual ,Nail lacquer, Butenafine HCl, Paronychia,Thioglycolic acid

"FORMULATION AND EVALUATION OF MEDICATED NAIL LACQUER OF BUTENAFINE HCl FOR EFFECTIVE TREATMENT OF PARONYCHIA", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.5, Issue 7, page no.319-343, July-2018, Available :http://www.jetir.org/papers/JETIR1807512.pdf

"FORMULATION AND EVALUATION OF MEDICATED NAIL LACQUER OF BUTENAFINE HCl FOR EFFECTIVE TREATMENT OF PARONYCHIA", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.5, Issue 7, page no. pp319-343, July-2018, Available at : http://www.jetir.org/papers/JETIR1807512.pdf